US 2002/0053637 A1Published application

Collection assemblies, laminates, and autosensor assemblies for use in transdermal sampling systems

AssigneeCygnus, Inc.

InventorsThomas E. Conn, Russell Ford, Pravin L. Soni, Michael J. Tierney, Prema Vijayakumar

Life of this patent

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Abstract

The invention relates generally to consumable components of a device used for continually or continuously measuring the concentration of target chemical analytes present in a biological system. More particularly, the invention relates to collection assemblies, laminate structures, and autosensor assemblies, which are used in connection with a transdermal sampling device. In one aspect, the invention includes autosensor assemblies which include laminate structures, electrode assemblies, and support trays. One important application of the invention involves an autosensor assembly for use in a blood glucose monitoring device.

Claims48

Dependent claims

A collection assembly, for use in a iontophoretic sampling device useful to monitor a selected analyte or derivatives thereof present in a biological system, said collection assembly comprising

a) a collection insert layer comprised of an ionically conductive material having first and second portions, each portion having first and second surfaces,
b) a mask layer comprised of a material that is substantially impermeable to the selected analyte or derivatives thereof, wherein the mask layer (i) has inner and outer faces and said outer face provides contact with said biological system and the inner face is positioned in facing relation with the first surface of each collection insert, (ii) defines first and second openings that are aligned with the first and second portions of the collection insert layer, (iii) each opening exposes at least a portion of the first surface of the collection insert layer, and (iv) has a border which extends beyond the first surface of each portion of the collection insert layer to provide an overhang;
and
(c) a retaining layer having (i) inner and outer faces wherein the inner face is positioned in facing relation with the second surface of each collection insert, (ii) defines first and second openings that are aligned with the first and second portions of the collection insert layer, (iii) each opening exposes at least a portion of the second surface of the collection insert layer, and (iv) has a border which extends beyond the first surface of each portion of the collection insert layer to provide an overhang.

1 more element

An autosensor assembly for use in a iontophoretic sampling device useful to monitor an analyte present in a biological system, said autosensor assembly comprising,

(I) a collection assembly said collection assembly comprising,
a) a collection insert layer comprised of an ionically conductive material having first and second portions, each portion having first and second surfaces,
b) a mask layer comprised of a substantially planar material that is substantially impermeable to the selected analyte or derivatives thereof, wherein the mask layer (i) has inner and outer faces and said outer face provides contact with said biological system and the inner face is positioned in facing relation with the first surface of each collection insert, (ii) defines first and second openings that are aligned with the first and second portions of the collection insert layer, (iii) each opening exposes at least a portion of the first surface of the collection insert layer, and (iv) has a border which extends beyond the first surface of each portion of the collection insert layer to provide an overhang;
(c) a retaining layer having (i) inner and outer faces wherein the inner face is positioned in facing relation with the second surface of each collection insert, (ii) defines first and second openings that are aligned with the first and second portions of the collection insert layer, (iii) each opening exposes at least a portion of the second surface of the collection insert layer, and (iv) has a border which extends beyond the first surface of each portion of the collection insert layer to provide an overhang;
and
(d) where the first and second openings in the mask layer are positioned in the collection assembly such that they are aligned with the first and second openings in the retaining layer and thereby define a plurality of flow paths through said collection assembly;
(II) an electrode assembly having an inner and outer face, the inner face comprising first and second bimodal electrodes, wherein the first and second bimodal electrodes are aligned with the first and second openings in the retaining layer of the collection assembly;
and
(III) a support tray that contacts the outer face of the electrode assembly.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/006,625Filed 30 Nov 2001
Priority: 13 May 1998
Published: 9 May 2002
Term ends: Not estimatedThe source records don’t support an estimate.

Classification2 codes

A61B 5/1486
Using chemical or electrochemical methods, e.g. by polarographic means: using enzyme electrodes, e.g. with immobilised oxidase
A61B
Medical diagnosis and surgery

Family

Application60/085,345Us provisional application · filed 13 May 1998
Application09/309,616Continuation · filed 11 May 1999
Application09/810,917Continuation · filed 16 Mar 2001
Application10/006,625Continuation · filed 30 Nov 2001
US 2002/0004640 A1Published application
US 6,341,232 B1Related patent
US 6,393,318 B1Related patent
US 6,438,414 B1Related patent
US 2002/0053637 A1This patent

From the US filing history. Foreign family members aren’t listed.