Leukocyte reduction filtration media
AssigneeWhatman Hemasure, Inc.
InventorsEric K. Lee, Paul J. Vernucci, Samuel C. Williams
Life of this patent
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Abstract
A high capacity leukocyte depletion filtration media incorporates a high specific surface area components with a matrix of fibers, yielding a filtration medium that removes leukocytes by at least 99.99%. The filtration medium uses a significantly low weight ratio of high specific surface area components to the matrix of fibers. The high specific area creates a multitude of adhesion sites for leukocytes while the low weight ratios allow good filtration flow rates. The filtration medium is incorporated into a filter device for removing leukocytes from biological fluids.
Claims63
A filtration media for depleting leukocytes from leukocyte-containing blood products, said filtration media comprising a matrix of fibers and a plurality of high specific surface area components distributed amongst the fibers, wherein the weight ratio of the high specific surface area components distributed amongst the matrix of fibers to the matrix of fibers is less than or equal to about 1:100, wherein use of said filtration media removes at least 99.99% of the leukocytes.
A filtration media for depleting leukocytes from leukocyte-containing blood products, said filtration media comprising a matrix of glass fibers;
- a plurality of high specific surface area polyacrylonitrile copolymer highly fibrillated fibers or particles distributed amongst the glass fibers, wherein the weight ratio of the highly fibrillated fibers or particles to the matrix fibers is less than about 1:200;
- and a binder comprised of polyvinyl alcohol or a cross-linked derivative thereof.
A method for depleting leukocytes from leukocyte-containing blood products, said method comprising passing the blood product through a leukocyte reduction filtration media comprised of a matrix of fibers and a plurality of high specific surface area components distributed amongst the matrix of fibers, wherein the weight ratio of the high surface area components distributed amongst the matrix fibers to the matrix fibers is less than or equal to about 1:100;
- removing at least 99.99% of the leukocytes from the blood product;
- and recovering a leukocyte-depleted blood product.
A filter device for depleting leukocytes from leukocyte-containing blood products, said device comprising a housing having an inlet and an outlet and having one or more layers of leukocyte depletion filtration media disposed therein, said media comprising a matrix of fibers and a plurality of high specific surface area components distributed amongst the matrix of fibers, wherein the weight ratio of high specific surface area components distributed amongst the matrix of fibers to the matrix of fibers is less than or equal to about 1:100 wherein use of said filtration device removes 99.99% of the leukocytes.
A filter device for depleting leukocytes from leukocyte-containing blood products comprising:
- a housing having an inlet and an outlet and having one or more layers of leukocyte depletion filtration media disposed therein, said media comprising a matrix of fibers and a plurality of high specific surface area components distributed amongst the matrix of fibers, wherein the weight ratio of the high specific surface area components to the matrix of fibers is less than about 1:200 and wherein during use said filtration media removes at least 99.99% of leukocytes;
- a prefilter, located upstream of said one or more layers of leukocyte depletion media, having a layer of needle punched fabric;
- and
- a particle trap located downstream of said one or more layers of leukocyte depletion media, having a first thin polyester screen, a layer of non-woven polyester, and a second thin polyester screen.
A filtration media for depleting leukocytes from leucocyte-containing blood products, said filtration media comprising a matrix of fibers and a plurality of components having a specific surface area of at least 100 m2/gm distributed amongst components having a specific surface area of at least 100 m2/gm wherein use of said filtration media removes at least 99.99% of the leukocytes.
A filtration media for depleting leukocytes from leukocyte-containing blood products, said filtration media comprising a matrix of glass fibers;
- a plurality of polyacrylonitrile copolymer highly fibrillated fibers or particles having a specific surface area of at least 120 m2/gm distributed amongst the glass fibers;
- and a binder comprised of polyvinyl alcohol or a cross-linked derivative thereof.
A method for depleting leukocytes from leukocyte-containing blood products, said method comprising passing the blood product through a leukocyte reduction filtration media comprised of a matrix of fibers and a plurality of high specific surface area components distributed amongst the matrix of fibers having a specific surface area of at least 100 m2/gm;
- removing at least 99.99% of the leukocytes from the blood product;
- and recovering a leukocyte-depleted blood product.
A filter device for depleting leukocytes from leukocyte-containing blood products, said device comprising a housing having an inlet and an outlet and having one or more layers of leukocyte depletion filtration media disposed therein, said media comprising a matrix of fibers and a plurality of high components distributed amongst the matrix of fibers having a specific surface area of at least 100 m2/gm wherein use of said filtration device removes 99.99% of the leukocytes.
A filter device for depleting leukocytes from leukocyte-containing blood products comprising:
- a housing having an inlet and an outlet and having one or more layers of leukocyte depletion filtration media disposed therein, said media comprising a matrix of fibers and a plurality of components having a specific surface area of at least 120 m2/gm distributed amongst the matrix of fibers wherein during use said filtration media removes at least 99.99% of leukocytes;
- a prefilter, located upstream of said one or more layers of leukocyte depletion media, having a layer of needle punched fabric;
- and
- a particle trap located downstream of said one or more layers of leukocyte depletion media, having a first thin polyester screen, a layer of non-woven polyester, and a second thin polyester screen.
Dependencies are inferred from the claim text.