Bis-phosphonate compounds
OwnerErik Arstad, Lars Skattebolinventors
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Abstract
The present invention provides a pharmaceutical compound, or pharmaceutically acceptable salt thereof, for use in medicine, wherein said compound is of formula I 1 wherein R is a pharmaceutically active moiety; Ar is an aromatic moiety; X is a linker group; and Y is a moiety comprising two phosphonate groups. Further aspects of the invention relate to a method for palliative and curative treatment of bone disorders and cancer related disorders, such as breast cancer.
Claims38
A pharmaceutical compound, or pharmaceutically acceptable salt thereof, for use in medicine, wherein said compound is of formula I
- R—Ar—X—Y I
- wherein
- R is a pharmaceutically active moiety;
- Ar is an aromatic moiety;
- X is a linker group;
- and
- Y is a moiety comprising two phosphonate groups:
A compound according to any preceding claim wherein said pharmaceutically active moiety comprises a radiolabel.
A pharmaceutical compound, or pharmaceutically acceptable salt thereof, for use in medicine, wherein said compound is of formula I
- R—Ar—X—Y I
- wherein
- R is a pharmaceutically active moiety;
- Ar is an aromatic moiety;
- X is a linker group;
- wherein X is selected from the group consisting of:
- a substituted or unsubstituted C1-4 alkylene group;
- substituted or unsubstituted C1-4 amine group, substituted or unsubstituted C1-4 ether group;
- substituted or unsubstituted C1-4 thioether group;
- S═O or SO2;
- and
- Y is a moiety comprising two phosphonate groups.
A pharmaceutical compound, or pharmaceutically acceptable salt thereof, for use in medicine, wherein said compound is of formula I
- R—Ar—X—Y I
- wherein
- Ar is an aromatic moiety;
- X is a linker group;
- Y is a moiety comprising two phosphonate groups;
- and
- R represents an optional substituent or group.
A pharmaceutical compound, or pharmaceutically acceptable salt thereof, for use in medicine, wherein said compound is of formula I
- R—Ar—X—Y I
- wherein
- Ar is an aromatic moiety;
- X is a linker group;
- wherein X is selected from the group consisting of:
- a substituted or unsubstituted C1-4 alkylene group;
- substituted or unsubstituted C1-4 amine group, substituted or unsubstituted C1-4 ether group;
- substituted or unsubstituted C1-4 thioether group;
- S═O or SO2;
- and
- Y is a moiety comprising two phosphonate groups;
- and
- R represents an optional substituent or group.
Dependencies are inferred from the claim text.