Self-aggregating protein compositions and use as sealants
AssigneeMeadox Medicals, Inc.
InventorsDan Castro, Al Kuehn, Moon Hae Sunwoo
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Abstract
There is described a bio-compatible aqueous slurry for forming a fluid-tight barrier on a surface of a porous implantable article. This aqueous slurry includes a self-aggregating protein comminutate having a substantially uniform particle size, a bio-compatible plasticizer and water. This aqueous slurry is further characterized by having a viscosity of about 8,000 centipoise to about 60,000 centipoise at 25° C. and a pH sufficient to maintain the protein suspended in the slurry.
Claims42
A bio-compatible aqueous slurry composition for forming a fluid-tight barrier on a surface of a porous implantable article comprising a self-aggregating protein comminutate having a substantially uniform particle size, a bio-compatible plasticizer, and water;
- said slurry further having a viscosity of about 8,000 centipoise to about 60,000 centipoise at 25° C. and a pH sufficient to maintain said protein comminutate suspended therewithin.
An implantable member for use in a body comprising:
- a flexible, porous polymeric substrate;
- and
- an aqueous sealant composition in intimate contact with said porous substrate, said sealant composition comprising:
- a slurry of a self-aggregating protein comminutate having a uniform particle size, a bio-compatible plasticizer,
- and water, wherein said sealant composition has a viscosity of about 8,000 centipoise to about 60,000 centipoise at 25° C. and a pH sufficient to maintain said protein comminutate suspended therewithin.
A process for making a bio-compatible aqueous sealant slurry for rendering implantable articles fluid-tight comprising:
- a) providing a paste containing a bio-absorbable self-aggregating protein;
- b) milling said paste at cryogenic temperatures to a powder having a uniform particle size;
- c) mixing said powder with a plasticizer and water to form said aqueous sealant slurry having a viscosity of about 8,000 centipoise to about 60,000 centipoise at 25° C.;
- and
- d) maintaining said slurry at a pH sufficiently outside of the isoelectric point of said paste to maintain said protein suspended within said slurry.
A process for preparing a fluid-tight implantable article comprising:
- a) providing an aqueous slurry containing a self-aggregating protein comminutate of uniform particle size, a bio-compatible plasticizer and water, said slurry also having a viscosity of about 8,000 centipoise to about 60,000 centipoise and a pH sufficient to maintain said protein suspended within said slurry;
- b) applying said slurry to a surface of a porous, flexible polymeric substrate with a force sufficient to ensure close association of said protein with said porous structure of said substrate, thereby sealing said article;
- and
- c) drying said slurry onto said substrate surface.
Dependencies are inferred from the claim text.