Therapeutic, diagnostic, or hydrophilic coating for an intracorporeal medical device

A method of providing a therapeutic, diagnostic or hydrophilic coating on an intracorporeal medical device, comprising:

• a) applying to the medical device a solution having a grafting component and a binding component, wherein the grafting component is selected from the group consisting of vinyl, acrylate and allyl compounds, and the binding component has at least a first functional group selected from the group consisting of aziridine, carbodiimide, aldehyde, isocyanate, succinimide, maleimide, oxirane, and carboxyl derivatized with carbodiimide or tresyl or succinimide;
• b) polymerizing the grafting component, so that the grafting component adheres to the device and bonds the binding component thereto, to form a base coat on the device;
• and
• c) applying to the base coat a solution of a therapeutic, diagnostic or hydrophilic agent having a functional group which covalently bonds to the binding component, to form the therapeutic, diagnostic or hydrophilic coating on the medical device.

A method of providing a therapeutic, diagnostic or hydrophilic coating on an intracorporeal medical device, comprising:

• a) applying to the medical device a solution having a grafting component and a binding component, wherein the grafting component is selected from the group consisting of vinyl, acrylate and allyl compounds, and the binding component has at least a first functional group selected from the group consisting of aziridine, carbodiimide, aldehyde, isocyanate, succinimide, maleimide, oxirane, and carboxyl derivatized with carbodiimide or tresyl or succinimide;
• b) polymerizing the grafting component, so that the grafting component adheres to the device and bonds the binding component thereto, to form a base coat on the device;
• c) applying to the base coat a solution comprising a linking agent having a functional group which covalently bonds to the binding component;
• and
• d) exposing the linking agent to a solution of a therapeutic, diagnostic or hydrophilic agent, so that a complex comprising the linking agent and the therapeutic, diagnostic or hydrophilic agent is formed, to form the therapeutic, diagnostic or hydrophilic coating on the medical device.

An intracorporeal medical device having a therapeutic, diagnostic, or hydrophilic coating, the coating comprising:

• a) a polymerized base coat on the device, comprising:
• a binding component having at least a first functional group selected from the group consisting of polyaziridine, polycarbodiimide, aldehyde, isocyanate, succinimide, maleimide, oxirane, and carboxyl derivatized with carbodiimide or tresyl or succinimide;
• and
• a grafting component selected from the group consisting of vinyl, acrylate and allyl compounds, adhered to the device and bonded to the binding component;
• and
• b) a top coat on the base coat, comprising a therapeutic, diagnostic or hydrophilic agent, or a complex of a therapeutic, diagnostic or hydrophilic agent and a linking agent, the therapeutic, diagnostic or hydrophilic agent or the linking agent having a functional group which bonds with the binding component, said functional group selected from the group consisting of carboxyl, hydroxy amine, and thiol, covalently bonded to the binding component.

An intracorporeal medical device having a lubricious hydrophilic coating, the coating comprising:

• a) a hydrophilic compound;
• b) an ionic compound with at least one inorganic ion;
• and
• c) a polymerized grafting component selected from the group consisting of vinyl and acrylate compounds, grafted to the device and crosslinked to the hydrophilic compound, containing uncrosslinked domains.