Cytoprotective Compounds
AssigneeVirginia Commonwealth University
InventorsRichard C. Franson, Raphael M. Ottenbrite
Life of this patent
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Abstract
The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for treating or prophylactically inhibiting phospholipase mediated injury, injury due to oxidation, and inflammation. In a very specific sense, this invention provides compositions and methods of making these compositions that are inhibitors of phospholipase.
Claims12
A composition comprising:
- 20
- wherein A comprises H, OH, a sugar moiety, an ether, an ester, an amide, NH2, or an acid or salt thereof;
- B is selected from the group consisting of N, NR, P, P═O, CH and CR, wherein R is an alkyl chain of 1 to 6 carbons and the chain may be functionalized or non-functionalized;
- C1, C2 and C3 are connecting groups which may be different and are selected from the group consisting of —(CH2)n— and (CH2CH2—O)y wherein n is an integer from 1 to 24,—(CH2)n— may be functionalized or non-functionalized, and y is an integer from 1 to 12;
- and
- D1 and D2 are fatty acid chains which may be different and are selected from the group consisting of fatty acid esters including CH3(CH2)n COO, and fatty acid amides of the form CH3(CH2)n CONH, wherein n is an integer from 1 to 32, at least one of the fatty chains is unsaturated at one or more positions, and the fatty chains may be of different lengths and may be unsaturated at different locations.
A composition comprising:
- 22
- wherein R1 is H or an aliphatic group which includes an acid group and R2 is an alkoxy group which includes a fatty moiety.
A composition comprising:
- 25
- wherein A comprises H, OH, a sugar moiety, an ether, an ester, an amide or NH2, or an acid or salt thereof;
- B is selected from the group consisting of C, —(CH2)nC—, N+, and (CH2)n N+, wherein n is an integer from 1 to 24, and the (CH2)n chain may be functionalized or non-functionalized;
- C1, C2, C3 and C4 may be different and are selected from the group consisting of (CH2)n and (CH2—CH2—O)y, wherein n is an integer from 1 to 24, the (CH2)n chain may be functionalized or nonfunctionalized, and y is an integer fiom 1 to 12;
- D1, D2 and D3 are selected from the group consisting of fatty acid chains, which may be different, and are selected from the group consisting of fatty acid esters consisting of CH3(CH2)nCOO and fatty acid amides consisting of CH3(CH2)n CONH, wherein n is an integer from 1 to 32, at least one of the fatty chains is unsaturated at one or more positions, the chains may be of different lengths and may be unsaturated at different locations, and H wherein only D1, D2 or D3 may be H;
- E is selected from the group consisting of H, a fatty acid amide consisting of CO(CH2)nCH3 or CO(CH2)nCOOH, wherein n is an integer from 0 to 24 and the alkyl (CH2)n chain may be functionalized or nonfunctionalized, or is the same as A-C4;
- and
- F is selected from the group consisting of N, NR, P, P═O, CH and CR, wherein R is an alkyl chain of 1 to 6 carbons which may be functionalized or non-functionalized.
A composition comprising:
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Dependencies are inferred from the claim text.