Estrogenic compounds as antiangiogenic agents

A method of inhibiting angiogenesis comprising administering to an endothelial cell an angiogenesis inhibiting amount of a compound of the general formula:

• 5
• a) Rb and Ro are independently —H, —Cl, —Br, —I, —F, —CN, lower alkyl, —OH, —CH2—OH, —NH2;
• or N(R6)(R7), wherein R6 and R7 are independently hydrogen or an alkyl or branched alkyl with up to 6 carbons;
• b)
• Ra is —N3, —CEN, —N3, —C═---C≡R, —C═CH-R, -R-C═CH2, —C≡CH, —O-R, -R-R1, or —O-R-R1 where R is a straight or branched alkyl with up to 10 carbons or aralkyl, and R1 is —OH, —NH2, —Cl, —Br, —I, —F or CF3;
• c)
• Z′ is >CH , >COH, or
• >C-R 2—OH, where R2 is an alkyl or bran ched alkyl with up to 10 carbons or aralkyl;
• d)
• >C-Rg is >CH2, >C(H)—OH, >C═O, >C═N—OH, >C(R3)OH, >C═N—OR3, >C(H)—NH2, >C(H)—NHR3, >C(H)—NR-R4, or >C(H)—C(O)-R3, where each R3 and R is independently an alkyl or branched alkyl with up to 10 carbons or aralkyl;
• and
• e) Z″ is >CH2, >C═O, >C(H)—OH, >C═N—OH, >C═N—OR5, >C(H)—C≡N, or >C(H)—NR5R5, wherein each R5 is independently hydrogen, an alkyl or branched alkyl with up to 10 carbons or aralkyl.