Method of preparing amino carboxylic acids
OwnerTodd J. Johnson, Michael K. Stern +4inventors
InventorsTodd J. Johnson, Michael K. Stern, David A. Morgenstern, Michael D. Rogers, Yvette M. Fobian, Jeffrey A. Levine
Life of this patent
Estimating the term…
Abstract
Novel compounds, N,N′-bis(phosphonomethyl)-N,N′-bis(hydroxycarbonylmethyl)urea and N,N,N′,N′-tetrakis(hydroxycarbonylmethyl)urea, suitable for use in preparing N-acyl aminocarboxylic acids that can be readily converted to N-(phosphonomethyl)glycine are provided. The compounds may be formed by the reaction of bis-(phosophonomethyl)urea or urea respectively with carbon monoxide and formaldehyde in the presence of a carboxymethylation catalyst precursor and solvent.
Claims17
An acetamide equivalent compound selected from the group consisting of compounds having the formula:
- 37
- wherein R13 and R14 are independently hydrogen, hydroxymethyl, alkyl, carboxymethyl, phosphonomethyl, or an ester or salt of carboxymethyl or phosphonomethyl;
- R15, R16 and R17 are independently alkyl or —NR3R4;
- and R3 and R4 are independently hydrogen, hydrocarbyl, or substituted hydrocarbyl.
A compound having the formula:
- 40
- wherein R1 is hydrogen, hydrocarbyl, substituted hydrocarbyl, —NR3R4, or —SR6;
- R3 and R4 are independently hydrogen, hydrocarbyl, or substituted hydrocarbyl;
- and
- R6 is hydrogen, hydrocarbyl, substituted hydrocarbyl, or a salt-forming cation.
The compound as set forth in claim 93, wherein R1 is —NR3R4.
Dependencies are inferred from the claim text.