Eliciting HCV-specific antibodies
AssigneeNovartis Vaccines and Diagnostics, Inc.
InventorsMichael Houghton, Mark Selby, Sergio Abrignani, Jens Martin Heile, Derek O'Hagan
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Abstract
Described herein is a method of eliciting antibodies and neutralizing of binding antibodies against a hepatitis C virus (HCV) E1E2 or E2 antigen using HCV E2 or HCV E1E2 polypeptides and/or HCV E2 or E1E2 polynucleotides. Elicitation of anti-E2 antibodies and anti-E2 NOB antibodies can be used, inter alia, to provide model systems to optimize anti-E2 antibody responses and/or anti-E2 NOB antibody responses to HCV and to provide prophylactic or therapeutic treatment against HCV infection.
Claims27
A method of eliciting an immune response against a hepatitis C virus (HCV) E2 or E1E2 antigen comprising the step of (a) administering to a subject a polynucleotide encoding the E2 or E1E2 antigen, wherein the E2 and E1E2 antigen is not secreted and wherein E2 is full-length.
Dependencies are inferred from the claim text.