Use of 5-HT(3) receptor antagonists for treating musculoeskeletal diseases
AssigneeNovartis AG
InventorsWolfgang Mueller, Thomas Stratz, Lothar Faerber
Life of this patent
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Abstract
The present invention relates to a new use for compounds having 5-HT3 (serotonin M) receptor antagonist activity, especially tropisetron, for the manufacture of a pharmaceutical composition for the treatment of a non-inflammatory local disease of the musculo-sceletal system, of a local irritation condition of a joint or tendon sheath, or for the local treatment a local manifestation at the locomotor apparatus of an inflammatory disease except for a crystal induced arthritis and a living pathogen induced inflammatory disease condition as long as the living pathogen is still present.
Claims11
The use of a 5-HT3 receptor antagonist or of a pharmaceutically acceptable salt of such an antagonist for the manufacture of a pharmaceutical composition for the treatment of:
- a) a non-inflammatory local disease of the musculo-sceletal system selected from the group consisting of myofasciale syndrome, tendomyosis, tendinosis, insertion tendopathy, bursopathy or periarthropathy, overload syndrome of the muscle, syndromes due to the compression of nerves or neuropathy and algodystrophy;
- b) a local irritation condition of a joint or tendon sheath related to a meniscus lesion, arthrosis, trauma, locally osteochondritis dissecans, osteonecrosis or joint chondromatosis, and various non-inflammatory rheumatoid diseases;
- or
- c) for the local treatment of a local manifestation at the locomotor apparatus of an inflammatory disease except for a crystal induced arthritis and a living pathogen induced inflammatory disease condition as long as the living pathogen is still present, wherein said inflammatory disease being selected from chronic polyarthritis, sarcoidosis, paraneoplastic syndrome or tumor-induced inflammatory diseases, turbid effusions, collagenosis, postinfectious arthritis, seronegative spondylarthritis and vasculitis.
A method of treating
- a) a non-inflammatory local disease of the musculo-sceletal system selected from the group consisting of myofasciale syndrome, tendomyosis, tendinosis, insertion tendopathy, bursopathy or periarthropathy, overload syndrome of the muscle, syndromes due to the compression of nerves or neuropathy and algodystrophy;
- b) a local irritation condition of a joint or tendon sheath related to a meniscus lesion, arthrosis, trauma, locally osteochondritis dissecans, osteonecrosis or joint chondromatosis, and various non-inflammatory rheumatoid diseases;
- or
- c) a local manifestation at the locomotor apparatus of an inflammatory disease except for a crystal induced arthritis and a living pathogen induced inflammatory disease condition as long as the living pathogen is still present, wherein said inflammatory disease being selected from chronic polyarthritis, sarcoidosis, paraneoplastic syndrome or tumor-induced inflammatory diseases, turbid effusions, collagenosis, postinfectious arthritis, seronegative spondylarthritis and vasculitis,
- in a subject in need thereof, which method comprises locally administering to said subject an effective amount of a 5-HT3 receptor antagonist.
A 5-HT3 receptor antagonist or a pharmaceutical composition comprising a 5-HT3 receptor antagonist for local use in the treatment of:
- a) a non-inflammatory local disease of the musculo-sceletal system selected from the group consisting of myofasciale syndrome, tendomyosis, tendinosis, insertion tendopathy, bursopathy or periarthropathy, overload syndrome of the muscle, syndromes due to the compression of nerves or neuropathy and algodystrophy;
- b) a local irritation condition of a joint or tendon sheath related to a meniscus lesion, arthrosis, trauma, locally osteochondritis dissecans, osteonecrosis or joint chondromatosis, and various non-inflammatory rheumatoid diseases;
- or
- c) a local manifestation at the locomotor apparatus of an inflammatory disease except for a crystal induced arthritis and a living pathogen induced inflammatory disease condition as long as the living pathogen is still present, wherein said inflammatory disease being selected from chronic polyarthritis, sarcoidosis, paraneoplastic syndrome or tumor-induced inflammatory diseases, turbid effusions, collagenosis, postinfectious arthritis, seronegative spondylarthritis and vasculitis.
Dependencies are inferred from the claim text.