Novel cyclohexene derivatives useful as antagonists of the motilin receptor

A compound of Formula (I):

• 9
• wherein
• R1 is selected from hydrogen, C1-5alkyl optionally substituted with halogen, aminoC1-5alkyl, C1-5alkylaminoC1-5alkyl, di-C1-5alkylaminoC1-5alkyl, C1-5alkylcarbonyl, C1-5alkoxycarbonyl, aminocarbonyl, C1-9alkylaminocarbonyl, cycloC3-9alkylaminocarbonyl, heteroarylaminocarbonyl optionally substituted with one or more C1-5alkyl, pyridinylcarbonyl optionally substituted with one or more substituents selected from the group consisting of halogen and C1-5alkyl, thiophenecarbonyl optionally substituted with one or more substituents selected from the group consisting of halogen and C1-5alkyl, phenyl, phenylC1-5alkyl, phenoxycarbonyl, phenylcarbonyl, diphenylmethylcarbonyl, phenylaminocarbonyl, phenylthiocarbonyl, phenylaminothiocarbonyl, said phenyl, phenylC1-5alkyl, phenoxycarbonyl, phenylcarbonyl, diphenylmethylcarbonyl, phenylaminocarbonyl, phenylthiocarbonyl, phenylaminothiocarbonyl being optionally substituted with one or more substituents selected from the group consisting of halogen, C1-5alkyl, trihalomethyl, C1-5alkoxy, amino, nitrile, nitro, C1-5alkylamino, and di-C1-5alkylamino, which substituents may be taken together to form a fused bicyclic aromatic ring or taken together with the phenyl ring to form a fused bicyclic 7-10 membered heterocyclic ring having one or two heteroatoms selected from oxygen, sulfur and nitrogen, and RaRbN-C1-5alkyl wherein Ra and Rb are independently selected from hydrogen and C1-5alkyl, or taken together to form a morpholine, piperazine, piperidine, or N-substituted piperidine wherein the N-substitutent is C1-5alkyl or phenylC1-5alkyl;
• R2 is selected from hydrogen, C1-5alkyl, C1-5alkoxy, phenyl optionally substituted with one or more substituents selected from the group consisting of halogen and C1-5alkyl, and phenylC1-5alkyl optionally substituted with one or more substituents selected from the group consisting of halogen, C1-5alkyl, C1-5alkoxy, halo and di-C1-5alkylamino;
• R3 is selected from hydrogen, C1-5alkylcarbonyl optionally substituted with halogen, and phenylcarbonyl optionally substituted with one or more substituents selected from the group consisting of halogen, C1-5alkyl, C1-5alkoxy, amino, C1-5alkylamino, and di-C1-5alkylamino;
• R4 is selected from hydrogen, C1-5alkyl, C1-5alkylcarbonyl optionally substituted with halogen, and phenylcarbonyl optionally substituted with one or more substituents selected from the group consisting of halogen, C1-5alkyl, C1-5alkoxy, amino, C1-5alkylamino, and di-C1-5alkylamino;
• n is 0-3;
• m is 1-5;
• R5 is
• 10
• wherein:
• q is 0-3;
• t is 0-1;
• X is oxygen, CH2, sulfur, hydroxy, thiol, or NRC, wherein
• Rc is selected from hydrogen, C1-5alkyl, morpholinoC1-5alkyl, piperidinylC1-5alkyl, N-phenylmethylpiperidinyl, and piperazinylC1-5alkyl,
• with the proviso that if q and t are 0, X is hydroxy, thiol, or amino,
• A is C1-5alkoxycarbonyl, phenylcarbonyl, or R7R8N—
• wherein R7 and R8 are independently selected from hydrogen, C1-5alkyl, and cycloC1-9alkyl, or R7 and R8 form a 5- or 6-membered heterocyclic ring with one or more heteroatoms selected from the group consisting of oxygen, nitrogen, sulfur, and sulfoxides and N-oxides thereof;
• and
• R6 is selected from hydrogen, halogen, C1-5alkoxy, C1-5alkylamino, and di-C1-5alkylamino;
• or a pharmaceutically acceptable salt thereof.