Pharmaceutical composition
OwnerHitoshi Ikeda, Takashi Sohda +1inventors
InventorsHitoshi Ikeda, Takashi Sohda, Hiroyuki Odaka
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Abstract
Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis and treatment of diabetes.
Claims29
Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with at least one member of the group consisting of an α-glucosidase inhibitor, an aldose reductase inhibitor, a biguanide, a statin compound, a squalene synthesis inhibitor, a fibrate compound, a LDL catabolism enhancer and an angiotensin converting enzyme inhibitor.
Pharmaceutical composition which comprises a compound represented by the formula:
- 11
- wherein R′ represents an optionally substituted hydrocarbon or heterocyclic group;
- Y represents a group represented by —CO—, —CH(OH)— or —NR3— (wherein R3 represents an optionally substituted alkyl group);
- m is 0 or 1;
- n is 0, 1 or 2;
- X represents CH or N;
- A represents a bond or a C1-7 divalent aliphatic hydrocarbon group;
- Q represents oxygen atom or sulfur atom;
- R1 represents hydrogen atom or an alkyl group;
- ring E may optionally have further 1 to 4 substituents, and the substituents may optionally be combined with R1 to form a ring;
- L and M respectively represent hydrogen atom, or L and M may optionally be combined with each other to form a bond;
- with a proviso that R′ does not represent benzopyranyl group when m and n are O, X represents CH, A represents a bond, Q represents sulfur atom, R1, L and M represent hydrogen atom and ring E does not have further substituents;
- or a pharmacologically acceptable salt thereof in combination with an insulin secretion enhancer and/or an insulin preparation.
Dependencies are inferred from the claim text.