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US 2002/0002178 A1Published application
Use of 5-thio-, sulfinyl- and sulfonylpyrazolo[3,4-b]- pyridines as cyclin dependent kinase inhibitors
AssigneeBristol-Myers Squibb Company
InventorRaj N. Misra
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Abstract
The present invention describes compounds of formula (I): 1 and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and n are as defined above. Compounds of formula (I) are protein kinase inhibitors and are useful in the treatment of proliferative diseases, for example, cancer, inflammation and arthritis. They may also be useful in the treatment of Alzheimer's disease and cardiovascular disease.
Claims27
A compound of formula I:
- 18
- or a pharmaceutically acceptable salt thereof wherein:
- R1 is hydrogen, lower alkyl, Cl;
- each R2 and R4 is, independently, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl or heterocycloalkylalkyl;
- R3 is hydrogen or lower alkyl;
- and
- n is 0, 1 or2.
4 more elements
Dependencies are inferred from the claim text.