Apomorphine derivatives and methods for their use
AssigneeTAP Pharmaceutical Products, Inc.
InventorsPramod K. Gupta, Deborah Milkowski, Debra Sutkowski-Markmann
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Abstract
Apomorphine derivative compounds; pharmaceutically active compositions of apomorphine derivative compounds; and the use of apomorphine derivative compounds in methods for treating sexual dysfunction or for enhancing apomorphine effectiveness for patients treated with apomorphine are disclosed. The apomorphine derivatives may be esters, ethers, amides, mixed anhydrides, hemiacetals, glucuronates, sulfates or phosphonates. A preferred apomorphine derivative is norapomorphine.
Claims16
A compound of the structure
- 4
- wherein n is an integer of from one to four;
- R1 is selected from the group consisting of hydrogen, alkyl, —PO3H2, —SO3H, and glucuronyl;
- and,
- R2 at each occurrence is independently selected from the group consisting of hydrogen, alkyl, —PO3H2, —SO3H and glucuronyl;
- or a pharmaceutically acceptable salt thereof.
A method of treating sexual dysfunction in a patient in need of such treatment comprising
- administering a therapeutically effective amount of at least one apomorphine derivative selected from the group consisting of esters, ethers, amides, mixed anhydrides, hemiacetals, glucuronates, sulfates and phosphonates to said patient.
A method of treating sexual dysfunction in a patient in need of such treatment comprising
- administering a therapeutically effective amount of norapomorphine to said patient.
A method for enhancing apomorphine effectiveness in a patient treated with apomorphine comprising the step of
- co-administering a therapeutically effective amount of a combination of at least one apomorphine derivative selected from the group consisting of esters, ethers, amides, mixed anhydrides, hemiacetals, glucuronates, sulfates and phosphonates with apomorphine to said patient.
A method for enhancing apomorphine effectiveness in a patient treated with apomorphine comprising the step of
- co-administering a therapeutically effective amount of a combination of norapomorphine with apomorphine
- to said patient.
Dependencies are inferred from the claim text.