Morpholine and thiomorpholine tachykinin receptor antagonists

A compound which is selected from the group consisting of:

• 1) (+/−)-2-(3,5-bis(trifluoromethyl)benzyloxy)-3-phenyl- morpholine;
• 2) (2R,S)-(3,5-bis(trifluoromethyl)benzyloxy)-(3R)-phenyl-(6R)-methyl-morpholine;
• 3) (2R,S)-(3,5-bis(trifluoromethyl)benzyloxy)-(3S)-phenyl-(6R)-methyl-morpholine;
• 4) (+/−)-2-(3,5-bis(trifluoromethyl)benzyloxy)-3-phenyl-4-methylcarboxamido-morpholine;
• 5) (+/−)-2-(3,5-bis(trifluoromethyl)benzyloxy)-3-phenyl-4-methoxy-carbonylmethyl-morpholine;
• 6) 2-(2-(3,5-bis(trifluoromethyl)phenyl)ethenyl)-3-phenyl-5-oxo-morpholine;
• 7) 3-phenyl-2-(2-(3,5-bis(trifluoromethyl)phenyl)-ethyl)- morpholine;
• 8) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(S)-methyl-morpholine;
• 9) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6-(S)-methyl-morpholine;
• 10) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(S)-methyl-morpholine;
• 11) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6-(S)-methyl-morpholine;
• 12) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(R)-methyl-morpholine;
• 13) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)-methyl-morpholine;
• 14) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(R)-methyl-morpholine;
• 15) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)-methyl-morpholine;
• 16) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl- morpholine;
• 17) 4-(3-(1,2,4-triazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-morpholine;
• 18) 4-(3-(5-oxo-1H,4H-1,2,4-tniazolo)methyl)-2-(S)-(3,5-bis-(trifluoromethyl)benzyloxy)-3-(S)-phenyl-morpholine;
• 19) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(R)-methyl-morpholine;
• 20) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(R)-methyl-morpholine;
• 21) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6-(R)-methyl-morpholine;
• 22) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6-(R)-methyl-morpholine;
• 23) 2-(R)-(3,5-bis(trifluoromethyl)-benzyloxy)-3-(S)-phenyl-5-(S)-methyl-morpholine;
• 24) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(S)-methyl-morpholine;
• 25) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)-methyl-morpholine;
• 26) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)-phenyl-morpholine;
• 27) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)-phenyl-morpholine;
• 28) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)-phenyl-morpholine;
• 29) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)-phenyl-morpholine;
• 30) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-6-(R)-methyl-3-(S)-phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 31) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-6-(R)-methyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-3-(S)-phenyl-morpholine;
• 32) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl- morpholine;
• 33) 4-(3-(1,2,4-triazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)benzyloxy) -3-(R)-phenyl-morpholine;
• 34) 4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-2-(S)-(3,5-bis-(trifluoromethyl)benzyloxy) -3-(R)-phenyl-morpholine;
• 35) 4-(2-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoro-methyl)benzyloxy) -3-(R)-phenyl-morpholine;
• 36) 4-(4-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)benzyloxy) -3-(R)-phenyl-morpholine;
• 37) 4-(aminocarbonylmethyl)-2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-3-(R)-phenyl-morpholine;
• 38) 4-(2-(imidazolo)methyl)-2-(S)-(3 ,5-bis(trifluoromethyl)benzyloxy) -3-(S)-phenyl-morpholine;
• 39) 4-(4-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)benzyloxy) -3-(S)-phenyl-morpholine;
• 40) 4-(2-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)benzyloxy) -3-(S)-phenyl-6-(R)-methyl-morpholine;
• 41) 4-(4-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)benzyloxy) -3-(S)-phenyl-6(R)-methyl-morpholine;
• 42) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-((6-hydroxy)-hexyl) -3-(R)-phenyl-morpholine;
• 43) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(5-(methylaminocarbonyl)pentyl) -3-(R)-phenyl-morpholine;
• 44) 4-(3-(1,2,4-triazolo)methyl)-2-(3,5-dimethylbenzyloxy)-3-phenylmorpholine;
• 45) 4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-2-(3 ,5-dimethyl)-benzyloxy) -3-phenyl-morpholine;
• 46) 4-(3-(1,2,4-triazolo)methyl)-2-(3,5-di(tert-butyl)benzyloxy) -3-phenylmorpholine;
• 47) 4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-2-(3,5-di(tert-butyl)benzyloxy) -3-phenyl-morpholine;
• 48) 4-(3-(1,2,4-triazolo)methyl)-2-(3-(tert-butyl)-5-methylbenzyloxy) -3-phenyl-morpholine;
• 49) 4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-2-(3-(tert-butyl)-5-methylbenzyloxy)-3-phenyl-morpholine;
• 50) 4-(3-(1,2,4-triazolo)methyl)-2-(3-(trifluoro-methyl)-5-methyl-benzyloxy)-3-phenyl-morpholine;
• 51) 4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-2-(3-(trifluoromethyl)-5-methylbenzyloxy)-3-phenyl-morpholine;
• 52) 4-(3-(1,2,4-triazolo)methyl)-2-(3-(tert-butyl)-5-(trifluoromethyl)benzyloxy)-3-phenyl-morpholine;
• 53) 4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-2-(3-(tert-butyl)-5-(trifluoromethyl)benzyloxy)-3-phenyl-morpholine;
• 54) 4-(2-(imidazolo)methyl)-2-(3,5-dimethyl-benzyloxy)-3-phenyl-morpholine;
• 55) 4-(4-(imidazolo)methyl)-2-(3,5-dimethyl-benzyloxy)-3-phenyl-morpholine;
• 56) 4-(2-(imidazolo)methyl)-2-(3,5-di(tert-butyl)-benzyloxy)-3-phenyl-morpholine;
• 57) 4-(4-(imidazolo)methyl)-2-(3,5-di(tert-butyl)-benzyloxy)-3-phenyl-morpholine;
• 58) 4-(2-(imidazolo)methyl)-2-(3-(tert-butyl)-5-methylbenzyloxy)-3-phenyl-morpholine;
• 59) 4-(4-(imidazolo)methyl)-2-(3-(tert-butyl)-5-methylbenzyloxy)-3-phenyl-morpholine;
• 60) 4-(2-(imidazolo)methyl)-2-(3-(trifluoro-methyl)-5-methylbenzyloxy)-3-phenyl-morpholine;
• 61) 4-(4-(imidazolo)methyl)-2-(3-(trifluoro-methyl)-5-methylbenzyloxy)-3-phenyl-morpholine;
• 62) 4-(2-(imidazolo)methyl)-2-(3-(tert-butyl)-5-(trifluoromethyl)benzyloxy)-3-phenyl-morpholine;
• 63) 2-(S)-(3,5-dichlorobenzyloxy)-3-(S)-phenyl-morpholine;
• 64) 2-(S)-(3,5-dichlorobenzyloxy)-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-3-(S)-phenylmorpholine;
• 65) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(methoxycarbonylmethyl)-3-(S)-phenyl-morpholine;
• 66) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(carboxymethyl)-3-(S)-phenyl-morpholine;
• 67) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-((2-aminoethyl)aminocarbonylmethyl)-3-(S)-phenyl-morpholine;
• 68) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-((3-aminopropyl)amino carbonylmethyl)-3-(S)-phenylmorpholine;
• 69) 4-benzyl-5-(S),6-(R)-dimethyl-3-(S)-phenylmorpholinone and 4-benzyl-5-(R),6-(S)-dimethyl-3-(S)-phenyl-morpholinone;
• 70) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-[5-(S),6-(R) or 5-(R),6-(S)-dimethyl]-3-(S)-phenyl-morpholinone;
• 71) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-[5-(R),6-(S) or 5-(S),6-(R)-dimethyl]-3-(S)-phenyl-morpholinone;
• 72) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(3-(1,2,4-triazolo)methyl)-[5-(S),6-(R) or 5-(R),6-(S)-dimethyl]-3-(S)-phenyl-morpholinone;
• 73) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(3-(5-oxo-1H,4H-1,2,4-triazolo) methyl)-[5-(S),6-(R) or 5-(R),6-(S)-dimethyl]-3-(S)-phenyl-morpholinone;
• 74) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(3-(1,2,4-triazolo)methyl)-[5-(R),6-(S) or 5-(S),6-(R)-dimethyl]-3-(S)-phenyl-morpholinone;
• 75) 2-(S)-(3 ,5-bis(trifluoromethyl)benzyloxy)-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-[5-(R),6-(S) or 5-(S),6-(R)-dimethyl]-3-(S)-phenyl-morpholinone;
• 76) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(2-(1-(4-benzyl)piperidino)ethyl) -3-(S)-phenyl-morpholine;
• 77) 3-(S)-(4-fluorophenyl)-4-benzyl-2-morpholinone;
• 78) 2-(S)-(3,5-bis(trifuoromethyl)benzyloxy)-3-(S)-(4-fluorophenyl) -4-benzyl-morpholine;
• 79) 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-(4-fluorophenyl) morpholine;
• 80) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-(4-fluorophenyl) -4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl-morpholine;
• 81) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-((3-pyridyl)methyl carbonyl)-3-(R)-phenyl-morpholine;
• 82) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(methoxycarbonylpentyl)-3-(R)-phenyl-morpholine;
• 83) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(carboxypentyl)-3-(R)-phenyl-morpholine;
• 84) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(methylamino-carbonylpentyl)-6-oxo-hexyl)-3-(R)-phenyl-morpholine;
• 85) 2-(R)-(3,5-bis(trifluoromethyl)benzoyloxy)-3-(S)-phenyl-4-benzyl-morpholine;
• 86) 2-(R)-(1-(3,5-bis(trifluoromethyl)phenyl)ethenyloxy)-3-(S)-phenyl-4-benzyl-morpholine;
• 87) 2-(R)-(1-(S)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 88) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 89) 2-(R)-(1-(S)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl-morpholine;
• 90) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl-morpholine;
• 93) 2-(R)-(1-(S)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 94) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 95) 2-(R)-(1-(S)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1 ,2,4-triazolo)methyl-morpholine;
• 96) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl- morpholine;
• 98) 2-(R)-(1-(R)-(1-(3-(methyl)naphthyl))ethoxy)-3-(S)-phenyl-4-(4-(2-oxo-1 ,3-imidazolo)methyl-morpholine;
• 99) 2-(R)-(1-(R)-(3-(fluoro)-5-(trifluoromethyl)phenyl)ethoxy)-3-(S )-phenyl-morpholine;
• 100) 2-(R)-(1-(R)-(3-(fluoro)-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)- morpholine;
• 101) 2-(R)-(1-(R)-(3-(chloro)-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 102) 2-(R)-(1-(R)-(3-(chloro)-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)- morpholine;
• 103) 2-(R)-(1-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 104) 2-(R)-(1-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 105) 2-(R)-(1-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 106) 2-(R)-(1-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 107) 2-(R)-(1-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 108) 2-(R)-(1-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 109) 2-(R)-(1-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 110) 2-(R)-(1-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 111) 2-(R)-(1-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 112) 2-(R)-(1-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 113) 2-(R)-(1-(R)-(3-(isopropoxy)-5-trifluoromethyl)phenyl)ethoxy) -3-(S)-phenyl-morpholine;
• 114) 2-(R)-(1-(R)-(3-(isopropoxy)-5-trifluoromethyl)phenyl)ethoxy) -3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 115) 2-(R)-(1-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 116) 2-(R)-(1-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl -4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 117) 2-(R)-(1-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 118) 2-(R)-(1-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl -4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 121) 2-(R)-(1-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 122) 2-(R)-(1-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl -4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 123) 2-(R)-(1-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 124) 2-(R)-(1-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)- morpholine;
• 125) 2-(R)-(1-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 126) 2-(R)-(1-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl -4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 127) 2-(R)-(1-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 128) 2-(R)-(1-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-phenyl -4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 129) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 130) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 131) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)-4-chloro)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 132) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)-4-chloro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 133) 2-(R)-(1-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 134) 2-(R)-(1-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 135) 2-(R)-(1-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 136) 2-(R)-(1-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 153) 2-(R)-(1-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-morpholine;
• 154) 2-(R)-(1-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 157) 2-(R)-(1-(R)-(2-fluoro-5-trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 158) 2-(R)-(1-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 161) 2-(R)-(1-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-phenyl -4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 162) 2-(R)-(1-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1 ,2,4-triazolo)methyl)-morpholine;
• 165) 2-(R)-(1-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-phenyl -4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 166) 2-(R)-(1-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 169) 2-(R)-(1-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-phenyl -4-(2-imidazolo)methyl-morpholine;
• 170) 2-(R)-(1-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(2-imidazolo)methyl-morpholine;
• 173) 2-(R)-(1-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-phenyl -4-(4-iniidazolo)methyl-morpholine;
• 174) 2-(R)-(1-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-imidazolo)methyl-morpholine;
• 177) 2-(R)-(1-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-phenyl -4-(5-tetrazolo)methyl-morpholine;
• 178) 2-(R)-(1-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(5-tetrazolo)methyl-morpholine;
• 181) 2-(R)-(1-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-phenyl -4-(2-oxo-5H-pyrrol-4-yl)methyl-morpholine;
• 182) 2-(R)-(1-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-morpholine;
• 185) 2-(R)-(1-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-morpholine;
• 186) 2-(R)-(1-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 189) 2-(R)-(1-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)-phenyl -4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 190) 2-(R)-(1-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 193) 2-(R)-(1-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 194) 2-(R)-(1-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 197) 2-(R)-(1-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 198) 2-(R)-(1-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 201) 2-(R)-(1-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)-phenyl -4-(2-imidazolo)methyl)-morpholine;
• 202) 2-(R)-(1-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(2-imidazolo)methyl)-morpholine;
• 205) 2-(R)-(I1(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)-phenyl -4-(4-iniiidazolo)methyl-morpholinie;
• 206) 2-(R)-(1-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-imidazolo)methyl-morpholine;
• 209) 2-(R)-(1-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4-(5-tetrazolo)methyl-morpholine;
• 210) 2-(R)-(1-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(5-tetrazolo)methyl-morpholine;
• 213) 2-(R)-(1-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-morpholine;
• 214) 2-(R)-(1-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-morpholine;
• 217) 2-(R)-(1-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-morpholine;
• 218) 2-(R)-(1-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 221) 2-(R)-(1-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 222) 2-(R)-(1-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 225) 2-(R)-(1-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1,2,4-triazolo)methyl)-morpholine;
• 226) 2-(R)-(1-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 229) 2-(R)-(1-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo-1,3-imnidazolo)methyl)-morpholine;
• 230) 2-(R)-(1-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 233) 2-(R)-(1-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(2-imidazolo)methyl-morpholine;
• 234) 2-(R)-(1-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(2-imidazolo)methyl-morpholine;
• 237) 2-(R)-(1-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(4-imidazolo)methyl-morpholine;
• 238) 2-(R)-(1-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-imidazolo)methyl-morpholine;
• 241) 2-(R)-(1-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(5-tetrazolo)methyl-morpholine;
• 242) 2-(R)-(1-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(5-tetrazolo)methyl-morpholine;
• 245) 2-(R)-(1-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-morpholine;
• 246) 2-(R)-(1-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-morpholine;
• 249) 2-(R)-(1-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-morpholine;
• 250) 2-(R)-(1-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 253) 2-(R)-(1-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(3-(1,2,4-triazolo)methyl-morpholine;
• 254) 2-(R)-(1-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl-morpholine;
• 257) 2-(R)-(1-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 258) 2-(R)-(1-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 261) 2-(R)-(1-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl) morpholine;
• 262) 2-(R)-(1-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 265) 2-(R)-(1-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(2-imidazolo)methyl-morpholine;
• 266) 2-(R)-(1-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(2-imidazolo)methyl-morpholine;
• 269) 2-(R)-(1-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(4-imidazolo)methyl-morpholine;
• 270) 2-(R)-(1-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-imidazolo)methyl-morpholine;
• 273) 2-(R)-(1-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(5-tetrazolo)methyl-morpholine;
• 274) 2-(R)-(1-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(5-tetrazolo)methyl-morpholine;
• 277) 2-(R)-(1-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-morpholine;
• 278) 2-(R)-(1-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-morpholine;
• 281) 2-(R)-(1-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-morpholine;
• 282) 2-(R)-(1-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 285) 2-(R)-(1-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 286) 2-(R)-(1-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 289) 2-(R)-(1-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 290) 2-(R)-(1-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 293) 2-(R)-(1-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 294) 2-(R)-(1-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 297) 2-(R)-(1-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(2-imidazolo)methyl-morpholine;
• 298) 2-(R)-(1-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(2-imidazolo)methyl-morpholine;
• 301) 2-(R)-(1-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(4-imidazolo)methyl-morpholine;
• 302) 2-(R)-(1-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-imidazolo)methyl-morpholine;
• 305) 2-(R)-(1-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(5-tetrazolo)methyl-morpholine;
• 306) 2-(R)-(1-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(5-tetrazolo)methyl-morpholine;
• 309) 2-(R)-(1-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-morpholine;
• 310) 2-(R)-(1-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-morpholine;
• 313) 2-(R)-(1-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-morpholine;
• 314) 2-(R)-(1-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 317) 2-(R)-(1-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4-(3-1H,4H-1,2,4-triazolo)methyl-morpholine;
• 318) 2-(R)-(1-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl-morpholine;
• 321) 2-(R)-(1-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 322) 2-(R)-(1-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 325) 2-(R)-(1-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 326) 2-(R)-(1-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 329) 2-(R)-(1-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4-(2-irnidazolo)methyl-morpholine;
• 330) 2-(R)-(1-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(2-imidazolo)methyl-morpholine;
• 333) 2-(R)-(1-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4-(4-imidazolo)methyl-morpholine;
• 334) 2-(R)-(1-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-imidazolo)methyl-morpholine;
• 337) 2-(R)-(1-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4-(5-tetrazolo)methyl-morpholine;
• 338) 2-(R)-(1-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(5-tetrazolo)methyl-morpholine;
• 341) 2-(R)-(1-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-morpholine;
• 342) 2-(R)-(1-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-morpholine;
• 345) 2-(R)-(1-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-morpholine;
• 346) 2-(R)-(1-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 349) 2-(R)-(1-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 350) 2-(R)-(1-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 353) 2-(R)-(1-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 354) 2-(R)-(1-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 357) 2-(R)-(1-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl-morpholine;
• 358) 2-(R)-(1-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 361) 2-(R)-(1-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(2-imidazolo)methyl-morpholine;
• 362) 2-(R)-(1-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(2-imidazolo)methyl-morpholine;
• 365) 2-(R)-(1-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(4-imidazolo)methyl-morpholine;
• 366) 2-(R)-(1-(R)-(3-(t-butyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl -4-(4-imidazolo)methyl-morpholine;
• 369) 2-(R)-(1-(R)-(3-(t-butyl)phenyl)ethoxy)-3-(S)-phenyl-4-(5-tetrazolo)methyl-morpholine;
• 370) 2-(R)-(1-(R)-(3-(t-butyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl -4-(5-tetrazolo)methyl-morpholine;
• 373) 2-(R)-(1-(R)-(3-(t-butyl)phenyl)ethoxy)-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-morpholine;
• 374) 2-(R)-(1-(R)-(3-(t-butyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl -4-(2-oxo-5H-pyrrol-4-yl)methyl-morpholine;
• 378) 2-(R)-(1-(R)-(2,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)-morpholine;
• 379) 2-(R)-(1-(R)-(2,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 380) 2-(R)-(1-(R)-(2,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 381) 2-(R)-(1-(R)-(2,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 382) 2-(R)-(1-(R)-(3-(thiomethyl)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 383) 2-(R)-(1-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 384) 2-(R)-(1-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 385) 2-(R)-(1-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 386) 2-(R)-(1-(R)-(3-(thiomethyl)-5-(trifluoromethyl)phenyl)ethoxy) -3-(S)-phenyl-morpholine;
• 387) 2-(R)-(1-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy) -3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 388) 2-(R)-(1-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy) -3-(S)-phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 389) 2-(R)-(1-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy) -3-(S)-phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 394) 2-(R)-(1-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 395) 2-(R)-(1-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 396) 2-(R)-(1-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 397) 2-(R)-(1-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 398) 2-(R)-(1-(R)-(3-(fluoro)-5-(trifluoromethyl)phenyl)-ethoxy)-3-(S)-(4-fluorophenyl)-morpholine;
• 399) 2-(R)-(1-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 400) 2-(R)-(1-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 401) 2-(R)-(1-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 402) 2-(R)-(1-(R)-(3-(chloro)-5-(trifluoromethyl)phenyl)-ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 403) 2-(R)-(1-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 404) 2-(R)-(1-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 405) 2-(R)-(1-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 406) 2-(R)-(1-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 407) 2-(R)-(1-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 408) 2-(R)-(1-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 409) 2-(R)-(1-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 410) 2-(R)-(1-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 411) 2-(R)-(1-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 412) 2-(R)-(1-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 413) 2-(R)-(1-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 414) 2-(R)-(1-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 415) 2-(R)-(1-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 416) 2-(R)-(1-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 417) 2-(R)-(1-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 418) 2-(R)-(1-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 419) 2-(R)-(1-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 420) 2-(R)-(1-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1 ,2,4-triazolo)methyl)-morpholine;
• 421) 2-(R)-(1-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 422) 2-(R)-(1-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 423) 2-(R)-(1-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 424) 2-(R)-(1-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 425) 2-(R)-(1-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 426) 2-(R)-(1-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy) -3-(S)-(4-fluoro)phenyl-morpholine;
• 427) 2-(R)-(1-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy) -3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 428) 2-(R)-(1-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy) -3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 429) 2-(R)-(1-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy) -3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)- morpholine;
• 430) 2-(R)-(1-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 431) 2-(R)-(1-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 432) 2-(R)-(1-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 433) 2-(R)-(1 (R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 434) 2-(R)-(1-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 435) 2-(R)-(1-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 436) 2-(R)-(1-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 437) 2-(R)-(1-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 438) 2-(R)-(1-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 439) 2-(R)-(1-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1 ,2,4-triazolo)methyl)-morpholine;
• 440) 2-(R)-(1-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1 ,2,4-triazolo)methyl)-morpholine;
• 441) 2-(R)-(1-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1 ,3-imidazolo)methyl)-morpholine;
• 442) 2-(R)-(1-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 443) 2-(R)-(1-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1 ,2,4-triazolo)methyl)-morpholine;
• 444) 2-(R)-(1-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 445) 2-(R)-(1-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)- morpholine;
• 446) 2-(R)-(1-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 447) 2-(R)-(1-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 448) 2-(R)-(1-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 449) 2-(R)-(1-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 450) 2-(R)-(1-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 451) 2-(R)-(1-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 452) 2-(R)-(1-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 453) 2-(R)-(1-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 454) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 455) 2-(R)-1-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 456) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 457) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)- morpholine;
• 458) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 459) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 460) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 461) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)- morpholine;
• 462) 2-(R)-(1-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 463) 2-(R)-(I-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 464) 2-(R)-(1-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 465) 2-(R)-(1-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 466) 2-(R)-(I-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 467) 2-(R)-(1-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 468) 2-(R)-(1-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 469) 2-(R)-(1-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 494) 2-(R)-(1-(R)-(3-(thiomethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 495) 2-(R)-(1-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 496) 2-(R)-(-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 497) 2-(R)-(1-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 498) 2-(R)-(1-(R)-(3-(thiomethyl)-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 499) 2-(R)-(1-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 500) 2-(R)-(1-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 501) 2-(R)-(1-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)- morpholine;
• 506) 2-(R)-(1-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 507) 2-(R)-(1-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 508) 2-(R)-(1-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 509) 2-(R)-(1-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 510) 2-(R)-(1-(R)-(phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 511) 2-(R)-(1-(R)-(phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 512) 2-(R)-(1-(R)-(phenyl)ethoxy)-3-(S)-phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 513) 2-(R)-(1-(R)-(phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 514) 2-(R)-(1-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl morpholine;
• 515) 2-(R)-(1-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 516) 2-(R)-(1-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 517) 2-(R)-(1-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 518) 2-(R)-(1-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 519) 2-(R)-(1-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 520) 2-(R)-(1-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 521) 2-(R)-(1-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 522) 2-(R)-(1-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 523) 2-(R)-(1-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 524) 2-(R)-(1-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 525) 2-(R)-(1-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 526) 2-(R)-(1-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-morpholine;
• 527) 2-(R)-(1-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 528) 2-(R)-(1-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 529) 2-(R)-(1-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 530) 2-(R)-(l1-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-morpholine;
• 531) 2-(R)-(1-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1 ,2,4-triazolo)methyl)-morpholine;
• 532) 2-(R)-(1-(R)-(4-(flu oro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 533) 2-(R)-(1-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-1,3-imnidazolo)methyl)-morpholine;
• 534) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3-fluoro)phenyl-morpholine;
• 535) 2-(R)-(1-(R)-(3 ,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3-flu oro)phenyl-4.(3-(5-oxo-H,4H-1,2,4-triazolo)metiyl)- morpholine;
• 536) 2-(R)-(1-(R)-(3,5-bis(trifluoro methyl)phenyl)ethoxy)-3-(S)-(3-fluoro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 537) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3-fluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 538) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4-difluoro)phenyl-morpholine;
• 539) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4-difluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 540) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4-difluoro)phenyl-4-(3-(1 ,2,4-triazolo)methyl)-morpholine;
• 541) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4-difluoro)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 542) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4-dichloro)phenyl-morpholine;
• 543) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4-dichloro)phenyl-4-(3-(5-oxo-1H,4H-1,2 ,4-triazolo)methyl)-morpholine;
• 544) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4-dichloro)phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 545) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4-dichloro)phenyl-4-(4-(2-oxo-1,3-imiidazolo)methyl)-morpholine;
• 546) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4-dimethyl)phenyl-morpholine;
• 547) 2-(R)-(I-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4-dimethyl)phenyl-4-(3-(5-oxo-1H,4H-1 ,2,4-triazolo)methyl)-morpholine;
• 548) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4-dimethyl)phenyl-4-(3-(1 ,2,4-triazolo)methyl)-morpholine;
• 549) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4-dimethyl)phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 550) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-3,4-methylenedioxyphenyl-morpholine;
• 551) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-3,4-methylenedioxyphenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 552) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-3,4-methylenedioxyphenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 553) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-3,4-methylenedioxyphenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)- morpholine;
• 554) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2-naphthyl)-morpholine;
• 555) 2-(R)-(1 (R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2-naphthyl)-4-(3-(5-oxo-1H,4H-1 ,2,4-triazolo)methyl)-morpholine;
• 556) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2-naphthyl)-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 557) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2-naphthyl)-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 558) 2-(R)-(1-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)-phenyl -4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 559) 2-(R)-(1-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)-phenyl -4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 560) 2-(R)-(1-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)-phenyl -4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 561) 2-(R)-(1-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)-phenyl -4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 562) 2-(R)-(1-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 563) 2-(R)-(1-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 564) 2-(R)-(1-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl -4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 565) 2-(R)-(1-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl -4-(4-(2-oxo-1,3-imnidazolo)methyl)-morpholine;
• 566) 2-(R)-(1-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl -4-(3-(-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 567) 2-(R)-(1-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl -4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 568) 2-(R)-(1-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl -4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 569) 2-(R)-(1-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl -4-(4-(2-oxo-1 ,3-imidazolo)methyl)-morpholine;
• 570) 2-(R)-(1-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 571) 2-(R)-(1-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 572) 2-(R)-(1-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy) -3-(S)-phenyl-4-(3-(-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 573) 2-(R)-(1-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy) -3-(S)-phenyl-4-(4-(2-oxo-1 ,3-imidazolo)methyl)-morpholine;
• 574) 2-(R)-(1-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl -4-(3-(-1H,4H-1 ,2,4-triazolo)methyl)-morpholine;
• 575) 2-(R)-(1-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl -4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 576) 2-(R)-(1-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl -4-(3-(-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 577) 2-(R)-(1-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl -4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 578) 2-(R)-(1-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl -4-(3-(-1H,4H-1 ,2,4-triazolo)methyl)-morpholine;
• 579) 2-(R)-(1-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl -4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 580) 2-(R)-(1-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 581) 2-(R)-(1-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 582) 2-(R)-(1-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl -4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 583) 2-(R)-(1-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl -4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 584) 2-(R)-(1-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-phenyl -4-(3-(-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 585) 2-(R)-(1-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-phenyl -4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 586) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy) -3-(S)-phenyl-4-(3-(-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 587) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy) -3-(S)-phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 588) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy) -3-(S)-phenyl-4-(3-(-1H,4H-1,2,4-triazolo)methyl)-morpholine;
• 589) 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy) -3-(S)-phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 590) 2-(R)-(1-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(-1H,4H-1 ,2,4-triazolo)methyl)-morpholine;
• 591) 2-(R)-(1-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• 592) 2-(R)-(1-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(1,2,4-triazolo)methyl)-morpholine;
• 593) 2-(R)-(1-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2-oxo-1,3-imidazolo)methyl)-morpholine;
• or a pharmaceutically acceptable salt thereof.

A process for the preparation of a compound of structural formula IV:

• 37
• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is selected from the group consisting of:
• (1) hydrogen;
• (2) C1-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from:
• (a) hydroxy,
• (b) oxo,
• (c) C1-6 alkoxy,
• (d) phenyl-C1-3 alkoxy,
• (e) phenyl,
• (f) —CN,
• (g) halo, wherein halo is fluoro, chloro, bromo or iodo,
• (h) —NR9R10, wherein R9 and R10 are independently selected from:
• (i) hydrogen,
• (ii) C1-6 alkyl,
• (iii) hydroxy-C1-6 alkyl, and
• (iv) phenyl,
• (i) —NR9COR10, wherein R9 and R10 are as defined above,
• (j) —NR9CO2R10, wherein R9 and R10 are as defined above,
• (k) —CONR9R10, wherein R9 and R10 are as defined above,
• (l) —COR9, wherein R9 is as defined above,
• (m) —CO2R9, wherein R9 is as defined above;
• (n) heterocycle, wherein the heterocycle is selected from the group consisting of:
• (A) benzimidazolyl,
• (B) benzofuranyl,
• (C) benzothiophenyl,
• (D) benzoxazolyl,
• (E) furanyl,
• (F) imidazolyl,
• (G) indolyl,
• (H) isooxazolyl,
• (I) isothiazolyl,
• (J) oxadiazolyl,
• (K) oxazolyl,
• (L) pyrazinyl,
• (M) pyrazolyl,
• (N) pyridyl,
• (O) pyrimidyl,
• (P) pyrrolyl,
• (Q) quinolyl,
• (R) tetrazolyl,
• (S) thiadiazolyl,
• (T) thiazolyl,
• (U) thienyl,
• (V) triazolyl,
• (W) azetidinyl,
• (X) 1,4-dioxanyl,
• (Y) hexahydroazepinyl,
• (Z) piperazinyl,
• (AA) piperidinyl,
• (AB) pyrrolidinyl,
• (AC) tetrahydrofuranyl, and
• (AD) tetrahydrothienyl, and wherein the heterocycle is unsubstituted or substituted with one or more substituent(s) selected from:
• (i) C1-6 alkyl, unsubstituted or substituted with halo, —CF3,—OCH3, or phenyl,
• (ii) C1-6 alkoxy,
• (iii) oxo,
• (iv) hydroxy,
• (v) thioxo,
• (vi) —SR9, wherein R9 is as defined above,
• (vii) halo,
• (viii) cyano,
• (ix) phenyl,
• (x) trifluoromethyl,
• (xi) —(CH2)m—NR9R10, wherein m is 0, 1 or 2, and R9 and R10 are as defined above,
• (xii) —NR9COR10, wherein R9 and R10 are as defined above,
• (xiii) —CONR9R10, wherein R9 and R10 are as defined above,
• (xiv) —CO2R9, wherein R9 is as defined above, and
• (xv) —(CH2)m—OR9, wherein m and R9 are as defined above;
• (3) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from:
• (a) hydroxy,
• (b) oxo,
• (c) C1-6 alkoxy,
• (d) phenyl-C1-3 alkoxy,
• (e) phenyl,
• (f) —CN,
• (g) halo,
• (h) —CONR9R10 wherein R9 and R10 are as defined above,
• (i) —COR9 wherein R9 is as defined above,
• (j) —CO2R9, wherein R9 is as defined above,
• (k) heterocycle, wherein the heterocycle is as defined above;
• (4) C2-6 alkynyl;
• (5) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from:
• (a) hydroxy,
• (b) C1-6 alkoxy,
• (c) C1-6 alkyl,
• (d) C2-5 alkenyl,
• (e) halo,
• (f) —CN,
• (g) —NO2,
• (h) —CF3,
• (i) —(CH2)m—NR9R10, wherein m, R9 and R10 are as defined above,
• (j) —NR9COR10, wherein R9 and R10 are as defined above,
• (k) —NR9CO2R10, wherein R9 and R10 are as defined above,
• (l) —CONR9R10, wherein R9 and R10 are as defined above,
• (m) —CO2NR9R10, wherein R9 and R10 are as defined above,
• (n) —COR9, wherein R9 is as defined above;
• (o) —CO2R9, wherein R9 is as defined above;
• R2 and R3 are independently selected from the group consisting of:
• (1) hydrogen,
• (2) C1-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from:
• (a) hydroxy,
• (b) oxo,
• (c) C1-6 alkoxy,
• (d) phenyl-C1-3 alkoxy,
• (e) phenyl,
• (f) —CN,
• (g) halo,
• (h) —NR9R10, wherein R9 and R10 are as defined above,
• (i) —NR9COR10, wherein R9 and R10 are as defined above,
• (j) NR9CO2R10, wherein R9 and R10 are as defined above,
• (k) —CONR9R10, wherein R9 and R10 are as defined above,
• (l) —COR9, wherein R9 is as defined above, and
• (m) —CO2R9, wherein R9 is as defined above;
• (3) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from:
• (a) hydroxy,
• (b) oxo,
• (c) C1-6 alkoxy,
• (d) phenyl-C1-3 alkoxy,
• (e) phenyl,
• (f) —CN,
• (g) halo,
• (h) —CONR9R10 wherein R9 and R10 are as defined above,
• (i) —COR9 wherein R9 is as defined above,
• (j) —CO2R9, wherein R9 is as defined above;
• (4) C2-6 alkynyl;
• (5) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from:
• (a) hydroxy,
• (b) C1-6 alkoxy,
• (c) C1-6 alkyl,
• (d) C2-5 alkenyl,
• (e) halo,
• (f) —CN,
• (g) —NO2,
• (h) —CF3,
• (i) —(CH2)m—NR9R10, wherein m, R9 and R10 are as defined above,
• (j) —NR9COR10, wherein R9 and R10 are as defined above,
• (k) —NR9CO2R10, wherein R9 and R10 are as defined above,
• (l) —CONR9R10, wherein R9 and R10 are as defined above,
• (m) —CO2NR9R10, wherein R9 and R10 are as defined above,
• (n) —COR9, wherein R9 is as defimed above;
• (o) —CO2R9, wherein R9 is as defimed above;
• and the groups R1 and R2 may be joined together to form a heterocyclic ring selected from the group consisting of:
• (a) pyrrolidinyl,
• (b) piperidinyl,
• (c) pyrrolyl,
• (d) pyridinyl,
• (e) imidazolyl,
• (f) oxazolyl, and
• (g) thiazolyl,
• and wherein the heterocyclic ring is unsubstituted or substituted with one or more substituent(s) selected from:
• (i) C1-6alkyl,
• (ii) oxo,
• (iii) C1-6alkoxy,
• (iv) —NR9R10, wherein R9 and R10 are as defined above,
• (v) halo, and
• (vi) trifluoromethyl;
• and the groups R2 and R3 may be joined together to form a carbocyclic ring selected from the group consisting of:
• (a) cyclopentyl,
• (b) cyclohexyl,
• (c) phenyl,
• and wherein the carbocyclic ring is unsubstituted or substituted with one or more substituents selected from:
• (i) C1-6alkyl,
• (ii) C1-6alkoxy,
• (iii) —NR9R10, wherein R9 and R10 are as defined above,
• (iv) halo, and
• (v) trifluoromethyl;
• and the groups R2 and R3 may be joined together to form a heterocyclic ring selected from the group consisting of:
• (a) pyrrolidinyl,
• (b) piperidinyl,
• (c) pyrrolyl,
• (d) pyridinyl,
• (e) imidazolyl,
• (f) furanyl,
• (g) oxazolyl,
• (h) thienyl, and
• (i) thiazolyl,
• and wherein the heterocyclic ring is unsubstituted or substituted with one or more substituent(s) selected from:
• (i) C1-6alkyl,
• (ii) oxo,
• (iii) C1-6alkoxy,
• (iv) —NR9R10, wherein R9 and R10 are as defined above,
• (v) halo, and
• (vi) trifluoromethyl;
• X is selected from the group consisting of:
• (1) —O—,
• (2) —S—,
• (3) —SO—, and
• (4) —SO2—;
• R6, R7 and R8 are independently selected from the group consisting of:
• (1) hydrogen;
• (2) C1-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from:
• (a) hydroxy,
• (b) oxo,
• (c) C1-6 alkoxy,
• (d) phenyl-C1-3 alkoxy,
• (e) phenyl,
• (f) —CN,
• (g) halo,
• (h) —NR9R10, wherein R9 and R10 are as defined above,
• (i) —NR9COR10, wherein R9 and R10 are as defined above,
• (j) —NR9CO2R10, wherein R9 and R10 are as defined above,
• (k) —CONR9R10, wherein R9 and R10 are as defined above,
• (l) —COR9, wherein R9 is as defined above, and
• (m) —CO2R9, wherein R9 is as defined above;
• (3) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from:
• (a) hydroxy,
• (b) oxo,
• (c) C1-6 alkoxy,
• (d) phenyl-C1-3 alkoxy,
• (e) phenyl,
• (f) —CN,
• (g) halo,
• (h) —CONR9R10 wherein R9 and R10 are as defined above,
• (i) —COR9 wherein R9 is as defined above,
• (j) —CO2R9, wherein R9 is as defined above;
• (4) C2-6 alkynyl;
• (5) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from:
• (a) hydroxy,
• (b) C1-6 alkoxy,
• (c) C1-6 alkyl,
• (d) C2-5 alkenyl,
• (e) halo,
• (f) —CN,
• (g) —NO2,
• (h) —CF3,
• (i) —(CH2)m—NR9R10, wherein m, R9 and R10 are as defined above,
• (j) —NR9COR10, wherein R9 and R10 are as defined above,
• (k) —NR9CO2R10, wherein R9 and R10 are as defined above,
• (l) —CONR9R10, wherein R9 and R10 are as defined above,
• (m) —CO2NR9R10 wherein R9 and R10 are as defined above,
• (n) —COR9, wherein R9 is as defined above;
• (o) —CO2R9, wherein R9 is as defined above;
• (6) halo,
• (7) —CN,
• (8) —CF3,
• (9) —NO2,
• (10) —SR14, wherein R14 is hydrogen or C1-5alkyl,
• (11) —SOR14, wherein R14 is as defined above,
• (12) —SO2R14, wherein R14 is as defined above,
• (13) NR9COR10, wherein R9 and R10 are as defined above,
• (14) CONR9COR10, wherein R9 and R10 are as defined above,
• (15) NR9R10, wherein R9 and R10 are as defi ned above,
• (16) NR9CO2R10, wherein R9 and R10 are as defined above,
• (17) hydroxy,
• (18) C1-6alkoxy,
• (19) COR9, wherein R9 is as defined above,
• (20) CO2R9, wherein R9 is as defined above,
• (21) 2-pyridyl,
• (22) 3-pyridyl,
• (23) 4-pyridyl,
• (24) 5-tetrazolyl,
• (25) 2-oxazolyl, and
• (26) 2-thiazolyl;
• R11, R12 and R13 are independently selected from the defrnitions of R6, R7 and R8;
• Y is selected from the group consisting of:
• (1) a single bond,
• (2) —O—,
• (3) —S—,
• (4) —CO—,
• (5) —CH2—,
• (6) —CHR15—, and
• (7) —CR15R16—, wherein R15 and R16 are independently selected from the group consisting of:
• (a) C1-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from:
• (i) hydroxy,
• (ii) oxo,
• (iii) C1-6 alkoxy,
• (iv) phenyl-C1-3 alkoxy,
• (v) phenyl,
• (vi) —CN,
• (vii) halo,
• (viii) —NR9R10, wherein R9 and R10 are as defined above,
• (ix) —NR9COR10, wherein R9 and R10 are as defined above,
• (x) —NR9CO2R10, wherein R9 and R10 are as defined above,
• (xi) —CONR9R10, wherein R9 and R10 are as defined above,
• (xii) —COR9, wherein R9 is as defined above, and
• (xiii) —CO2R9, wherein R9 is as defined above;
• (b) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from:
• (i) hydroxy,
• (ii) C1-6 alkoxy,
• (iii) C1-6 alkyl,
• (iv) C2-5 alkenyl,
• (v) halo,
• (vi) —CN,
• (vii) —NO2,
• (viii) —CF3,
• (ix) —(CH2)m—NR9R10, wherein m, R9 and R10 are as defined above,
• (x) —NR9COR10, wherein R9 and R10 are as defined above,
• (xi) —NR9CO2R10, wherein R9 and R10 are as defined above,
• (xii) —CONR9R10, wherein R9 and R10 are as defined above,
• (xiii) —CO2NR9R10, wherein R9 and R10 are as defined above,
• (xiv) —COR9, wherein R9 is as defined above, and
• (xv) —CO2R9, wherein R9 is as defined above;
• Z is C1-6 alkyl;
• which comprises contacting a compound of formula V:
• 38
• wherein R1, R2, R3, R6, R7, R8, R11, R12 and R13 are as defined above;
• with an inorganic or an organic acid selected from the group consisting of:
• toluenesulfonic acid, methanesulfonic acid, sulfuric acid, hydrochloric acid and mixtures thereof,
• in an aprotic solvent selected from the group consisting of:
• toluene, benzene, dimethylformamide, tetrahydrofuran, diethylether, dimethoxyethane, ethyl acetate, and mixtures thereof,
• at a temperature from 0° C. to solvent reflux temperature for a sufficient time to produce a compound of structural formula IV.

A process for the preparation of a compound of structural formula XI:

• 39
• or a pharmnaceutically acceptable salt thereof, wherein:
• R1 is selected from the group consisting of:
• (1) hydrogen;
• (2) C1-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from:
• (a) hydroxy,
• (b) oxo,
• (c) C1-6 alkoxy,
• (d) phenyl-C1-3 alkoxy,
• (e) phenyl,
• (f) —CN,
• (g) halo,
• (h) —NR9R10, wherein R9 and R10 are independently selected from:
• (i) hydrogen,
• (ii) C1-6 alkyl,
• (iii) hydroxy-C1-6 alk;yl, and
• (iv) phenyl,
• (i) —NR9COR10, wherein R9 and R10 are as defined above,
• (j) —NR9CO2R10, wherein R9 and R10 are as defined above,
• (k) CONR9R10, wherein R9 and R10 are as defined above,
• (l) —COR9, wherein R9 is as defined above,
• (m) —CO2R9, wherein R9 is as defined above;
• (n) heterocycle, wherein the heterocycle is selected from the group consisting of:
• (A) benzimidazolyl,
• (B) benzofuranyl,
• (C) benzothiophenyl,
• (D) benzoxazolyl,
• (E) furanyl,
• (F) imidazolyl,
• (G) indolyl,
• (H) isooxazolyl,
• (I) isothiazolyl,
• (J) oxadiazolyl,
• (K) oxazolyl,
• (L) pyrazinyl,
• (M) pyrazolyl,
• (N) pyridyl,
• (l) pyrimidyl,
• (P) pyrrolyl,
• (Q) quinolyl,
• (R) tetrazolyl,
• (S) thiadiazolyl,
• (T) thiazolyl,
• (U) thienyl,
• (V) triazolyl,
• (W) azetidinyl,
• (X) 1,4-dioxanyl,
• (Y) hexahydroazepinyl,
• (Z) piperazinyl,
• (AA) piperidinyl,
• (AB) pyrrolidinyl,
• (AC) tetrahydrofuranyl, and
• (AD) tetrahydrothienyl,
• and wherein the heterocycle is unsubstituted or substituted with one or more substituent(s) selected from:
• (i) C1-6 alkyl, unsubstituted or substituted with halo, —CF3, —OCH3, or phenyl,
• (ii) C1-6 alkoxy,
• (iii) oxo,
• (iv) hydroxy,
• (v) thioxo,
• (vi) —SR9, wherein R9 is as defined above,
• (vii) halo,
• (viii) cyano,
• (ix) phenyl,
• (x) trifluoromethyl,
• (xi) —(CH2)m—NR9R10, wherein m is 0, 1 or 2, and R9 and R10 are as defined above,
• (xii) —NR9COR10, wherein R9 and R10 are as defined above,
• (xiii) —CONR9R10, wherein R9 and R10 are as defined above,
• (xiv) —CO2R9, wherein R9 is as defined above, and
• (xv) —(CH2)m—OR9, wherein m and R9 are as defined above;
• (3) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from:
• (a) hydroxy,
• (b) oxo,
• (c) C1-6 alkoxy,
• (d) phenyl-C1-3 alkoxy,
• (e) phenyl,
• (f) —CN,
• (g) halo,
• (h) —CONR9R10 wherein R9 and R10 are as defined above,
• (i) —COR9 wherein R9 is as defined above,
• (i) —CO2R9, wherein R9 is as defined above,
• (k) heterocycle, wherein the heterocycle is as defined above;
• (4) C2-6 alkynyl;
• (5) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from:
• (a) hydroxy,
• (b) C1-6 alkoxy,
• (c) C1-6 alkyl,
• (d) C2-5 alkenyl,
• (e) halo,
• (f) —CN,
• (g) —NO2,
• (h) —CF3,
• (i) —(CH2)m—NR9R10, wherein m, R9 and R10 are as defined above,
• (j) —NR9COR10, wherein R9 and R10 are as defined above,
• (k) —NR9CO2R10, wherein R9 and R10 are as defined above,
• (l) —CONR9R10, wherein R9 and R10 are as defined above,
• (m) —CO2NR9R10, wherein R9 and R10 are as defined above,
• (n) —COR9, wherein R9 is as defined above;
• (o) —CO2R9, wherein R9 is as defined above;
• R2 and R3 are independently selected from the group consisting of:
• (1) hydrogen,
• (2) C1-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from:
• (a) hydroxy,
• (b) oxo,
• (c) C1-6 alkoxy,
• (d) phenyl-C1-3 alkoxy,
• (e) phenyl,
• (f) —CN,
• (g) halo,
• (h) —NR9R10, wherein R9 and R10 are as defined above,
• (i) —NR9COR10, wherein R9 and R10 are as defined above,
• (j) —NR9CO2R10, wherein R9 and R10 are as defined above,
• (k) —CONR9R10, wherein R9 and R10 are as defined above,
• (l) —COR9, wherein R9 is as defined above, and
• (m) —CO2R9, wherein R9 is as defined above;
• (3) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from:
• (a) hydroxy,
• (b) oxo,
• (c) C1-6 alkoxy,
• (d) phenyl-C1-3 alkoxy,
• (e) phenyl,
• (f) —CN,
• (g) halo,
• (h) —CONR9R10 wherein R9 and R10 are as defined above,
• (i) —COR9 wherein R9 is as defined above,
• (j) —CO2R9, wherein R9 is as defined above;
• (4) C2-6 alkynyl;
• (5) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from:
• (a) hydroxy,
• (b) C1-6 alkoxy,
• (c) C1-6 alkyl,
• (d) C2-5 alkenyl,
• (e) halo,
• (f) —CN,
• (g) —NO2,
• (h) —CF3,
• (i) —(CH2)m-NR9R10, wherein m, R9 and R10 are as defined above,
• (j) —NR9COR10, wherein R9 and R10 are as defined above,
• (k) —NR9CO2R10, wherein R9 and R10 are as defined above,
• (l) —CONR9R10, wherein R9 and R10 are as defined above,
• (m) —CO2NR9R10, wherein R9 and R10 are as defined above,
• (n) —COR9, wherein R9 is as defined above;
• (o) —CO2R9, wherein R9 is as defined above;
• and the groups RI and R2 may be joined together to form a heterocyclic ring selected from the group consisting of:
• (a) pyrrolidinyl,
• (b) piperidinyl,
• (c) pyrrolyl,
• (d) pyridinyl,
• (e) imidazolyl,
• (f) oxazolyl, and
• (g) thiazolyl,
• and wherein the heterocyclic ring is unsubstituted or substituted with one or more substituent(s) selected from:
• (i) C1-6alkyl,
• (ii) oxo,
• (iii) C1-6alkoxy,
• (iv) —NR9R10, wherein R9 and R10 are as defined above,
• (v) halo, and
• (vi) trifluoromethyl;
• and the groups R2 and R3 may be joined together to form a carbocyclic ring selected from the group consisting of:
• (a) cyclopentyl,
• (b) cyclohexyl,
• (c) phenyl,
• and wherein the carbocyclic ring is unsubstituted or substituted with one or more substituents selected from:
• (i) C1-6alkyl,
• (ii) C1-6aLkoxy,
• (iii) —NR9R10, wherein R9 and R10 are as defined above,
• (iv) halo, and
• (v) trifluoromethyl;
• and the groups R2 and R3 may be joined together to form a heterocyclic ring selected from the group consisting of:
• (a) pyrrolidinyl,
• (b) piperidinyl,
• (c) pyrrolyl,
• (d) pyridinyl,
• (e) imidazolyl,
• (f) furanyl,
• (g) oxazolyl,
• (h) thienyl, and
• (i) thiazolyl,
• and wherein the heterocyclic ring is unsubstituted or substituted with one or more substituent(s) selected from:
• (i) C1-6alkyl,
• (ii) oxo,
• (iii) C1-6alkoxy,
• (iv) —NR9R10, wherein R9 and R10 are as defined above,
• (v) halo, and
• (vi) trifluoromethyl;
• R6, R7 and R8 are independently selected from the group consisting of:
• (1) hydrogen;
• (2) C1-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from:
• (a) hydroxy,
• (b) oxo,
• (c) C1-6 alkoxy,
• (d) phenyl-C1-3 alkoxy,
• (e) phenyl,
• (f) —CN,
• (g) halo,
• (h) —NR9R10, wherein R9 and R10 are as defined above,
• (i) —NR9COR10, wherein R9 and R10 are as defined above,
• (j) —NR9CO2R10, wherein R9 and R10 are as defined above,
• (k) —CONR9R10, wherein R9 and R10 are as defined above,
• (l) —COR9, wherein R9 is as defined above, and
• (m) —CO2R9, wherein R9 is as defined above;
• (3) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from:
• (a) hydroxy,
• (b) oxo,
• (c) C1-6 alkoxy,
• (d) phenyl-C1-3 alkoxy,
• (e) phenyl,
• (f) —CN,
• (g) halo,
• (h) —CONR9R10 wherein R9 and R10 are as defined above,
• (i) —COR9 wherein R9 is as defined above,
• (j) —CO2R9, wherein R9 is as defined above;
• (4) C2-6 alkynyl;
• (5) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from:
• (a) hydroxy,
• (b) C1-6 alkoxy,
• (c) C1-6 alkyl,
• (d) C2-5 alkenyl,
• (e) halo,
• (f) —CN,
• (g) —NO2,
• (h) —CF3,
• (i) —(CH2)m—NR9R10, wherein m, R9 and R10 are as defined above,
• (j) —NR9COR10, wherein R9 and R10 are as defined above,
• (k) —NR9CO2R10, wherein R9 and R10 are as defined above,
• (l) —CONR9R10, wherein R9 and R10 are as defined above,
• (m) —CO2NR9R10, wherein R9 and R10 are as defined above,
• (n) —COR9, wherein R9 is as defined above;
• (o) —CO2R9, wherein R9 is as defined above;
• (6) halo,
• (7) —CN,
• (8) —CF3,
• (9) —NO2,
• (10) —SR14, wherein R14 is hydrogen or C1-6alkyl,
• (11) —SOR14, wherein R14 is as defined above,
• (12) —SO2R14, wherein R14 is as defined above,
• (13) NR9COR10, wherein R9 and R10 are as defined above,
• (14) CONR9COR10, wherein R9 and R10 are as defined above,
• (15) NR9R10, wherein R9 and R10 are as defined above,
• (16) NR9CO2R10, wherein R9 and R10 are as defined above,
• (17) hydroxy,
• (18) C1-6alkoxy,
• (19) COR9, wherein R9 is as defined above,
• (20) CO2R9, wherein R9 is as defined above,
• (21) 2-pyridyl,
• (22) 3-pyridyl,
• (23) 4-pyridyl,
• (24) 5-tetrazolyl,
• (25) 2-oxazolyl, and
• (26) 2-thiazolyl;
• R11, R12 and R13 are independently selected from the definitions of R6, R7 and R8;
• Z is C1-6 alkyl;
• which comprises contacting a compound of formula IX:
• 40
• wherein R1, R2, R3, R11, R12 and R13 are defined as above;
• with a hydride reducing agent selected from a group consisting of:
• diisobutylaluminum hydride:
• lithium tri(sec-butyl)borohydride:
• and lithium aluminum hydride;
• in an organic solvent at low temperature;
• followed by acylation of the resultant alcohol/alkoxide with a substituted benzoyl halide, substituted benzoic anhydride, substituted benzoic mixed anhydride or substituted activated benzoate ester (e.g. p-nitrophenyl ester or N-hydroxysuccinimide ester), in which the phenyl ring of these acylating agents is substituted with R6, R7, and R8 as defined above, in an organic solvent at low temperature for a sufficient time to produce a compound of structural formula X:
• 41
• and subsequently contacting the compound of formula X with a titanium ylide (generated from reagents selected from:
• μ-chloro-μ-methylene-(bis(cyclopentadienyl)titanium)dimethylamluminum;
• or dimethyl titanocene;
• or the reagent prepared by the reduction of a 1,1-dibromoalkane with zinc and titanium tetrachloride in the presence of N,N,N′,N′-tetramethylethylenediamine) to afford an enol ether which is then hydrogenated in the presence of a a catalyst selected from palladium on carbon, platinum on carbon, or rhodium on carbon to afford the compound of formula XI.