Antibacterial aqueous ophthalmic formulations containing ofloxacin and use of chitosan for solubilizing ofloxacin suspended in an aqueous media
AssigneeLaboratoire Medidom S.A.
InventorsRobert Gurny, Olivia Mireille Felt
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Abstract
The aqueous ophthalmic formulation for the treatment and prevention of infections contains ofloxacin as active ingredient and a chitosan having a weight average molecular weight of 500,000-5,000,000 Daltons and a deacetylation degree of 30-90% as solubilizing agent of ofloxacin. Chitosan having a deacetylation degree of 30-90% may be also used for solubilizing ofloxacin suspended in an aqueous media having a substantially neutral pH in any other applications.
Claims15
An aqueous ophthalmic formulation for the treatment and prevention of infections containing ofloxacin as active ingredient and a chitosan having a weight average molecular weight of 500,000-5,000,000 Daltons and a deacetylation degree of 30-90% as solubilizing agent of ofloxacin.
Use of a chitosan having a weight average molecular weight of 500,000-5,000,000 Daltons and a deacetylation degree of 30-90% as solubilizing agent of ofloxacin for the preparation of an aqueous ophthalmic formulation containing ofloxacin for treating bacterial infections.
Use of a chitosan having a deacetylation degree of 30-90% for solubilizing ofloxacin suspended in an aqueous media having a substantially neutral pH.
Dependencies are inferred from the claim text.