PAI-2 conjugates for the treatment and imaging of cancer
AssigneesPAI-2 Pty Limited, University of Wollongong, Medical Scitec Australia Pty Ltd.
InventorsMarie Ranson, Barry John Allen, Clive Leighton Bunn
Life of this patent
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Abstract
A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises PAI-2 or a functional derivative, homologue, analogue, chemical equivalent or mimetic thereof, which PAI-2 is bound, linked, or otherwise associated with a toxin or label.
Claims31
A method of treating a condition in a mammal, which condition is characterized by the undesirable, detrimental or otherwise unwanted growth of cells expressing a uPA/uPAR complex, said method comprising administering to said mammal an effective amount of PAI-2 or functional derivative, equivalent, homologue, analogue or mimetic thereof, which PAI is bound, linked or otherwise associated with a toxin, for a time and under conditions sufficient to down-regulate the growth of said cells.
A method of down-regulating the growth of cells expressing a uPA/uPAR complex, said method comprising contacting said cells with an effective amount of PAI-2 or functional derivative, equivalent, homologue, analogue or mimetic thereof, which PAI-2 is bound, linked or otherwise associated with a toxin.
A PAI-2 conjugate molecule comprising PAI-2 or functional derivative, homologue, analogue, chemical equivalent or mimetic thereof, which PAI-2 is bound, linked or otherwise associated with a toxin or label.
A pharmaceutical composition comprising a PAI-2 conjugate molecule comprising PAI-2 or functional derivative, homologue, analogue, chemical equivalent or mimetic thereof, which PAI-2 is bound, linked or otherwise associated with a toxin or label in association with one or more pharmaceutically acceptable carriers and/or diluents.
A method of detecting or visualizing cancerous cells, said method comprising contacting cells with a PAI-2 conjugate molecule comprising PAI-2 or functional derivative, homologue, analogue, chemical equivalent or mimetic thereof, which PAI-2 is bound, linked or otherwise associated with a label capable of being detected, and determining the cells which express a uPA/uPAR complex by detection or visualization.
Dependencies are inferred from the claim text.