Stabilized granulocyte colony stimulating factor
AssigneePfizer Inc.
InventorsKathleen Brimelow Williams, Josephine Nanette Hay
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Abstract
The invention relates to stable aqueous compositions of granulocyte colony stimulating factor that have a pH in the range of pH 5 to pH 8 and comprise a salt comprising sulfate ions, and to uses thereof.
Claims41
An aqueous composition comprising granulocyte colony stimulating factor and having a pH of from about 5.0 to about 8.0, and a salt comprising sulfate ions, wherein the salt is present at a concentration of from about 0.01 M to about 1.0 M.
A method of treating granulocytopenia in a mammal, comprising administering to a mammal in need of such treatment, a therapeutically effective dose of granulocyte colony stimulating factor in an aqueous composition having a pH of from about 5.0 to about 8.0, which aqueous composition comprises a salt comprising sulfate ions, wherein the salt is present at a concentration of from about 0.01 M to about 1.0 M.
A method of treating infectious disease in a mammal, comprising administering to a mammal in need of such treatment, a therapeutically effective dose of granulocyte colony stimulating factor in an aqueous composition having a pH of from about 5.0 to about 8.0, which aqueous composition comprises a salt comprising sulfate ions, wherein the salt is present at a concentration of from about 0.01 M to about 1.0 M.
Dependencies are inferred from the claim text.