Methods and compositions for inhibiting angiogenesis
AssigneeNorthwestern University
InventorsNoel P. Bouck, David W. Dawson, Paul R. Gillis
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Abstract
The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous SLED to cells associated with the tissue. The presence of exogenous SLED inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of SLED within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of SLED.
Claims25
A method of inhibiting angiogenesis within a tissue, said method comprising providing exogenous SLED to endothelial cells associated with said tissue under conditions sufficient for said SLED to inhibit angiogenesis within said tissue.
A method of inhibiting endothelial cell migration, said method comprising providing exogenous SLED to said cells under conditions sufficient for said SLED to inhibit endothelial cell migration.
A method for stimulating the growth of hair in a mammal, said method comprising providing exogenous SLED to cells associated with the skin of said mammal under conditions sufficient for said SLED to stimulate the growth of hair in said mammal.
A method for inhibiting the growth of a tumor, said method comprising providing exogenous SLED to endothelial cells associated with said tumor under conditions sufficient for said SLED to inhibit the migration of said endothelial cells within and to said tumor such that the growth of said tumor is inhibited.
A pharmacological composition comprising a source of SLED and a suitable diluent.
A method for determining the severity of a tumor by assaying for the presence of SLED within the tumor, wherein the absence of SLED within the tumor indicates an advanced state and the presence of SLED within the tumor indicates an early state of said tumor.
Dependencies are inferred from the claim text.