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US 2002/0001591 A1Published application
Compositions for the delivery of antigens
AssigneeEmisphere Technologies, Inc.
InventorsNoemi B. Santiago, Susan Haas, Andrea Leone-Bay, Sam J. Milstein, Evgueni Barantsevitch
Life of this patent
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Abstract
The present invention relates to compositions and methods for orally delivering antigens. The antigen and an adjuvant are combined with an acylated amino acid or polyamino acid and, a sulfonated amino acids or polyamino acid, or a salt of the foregoing.
Claims22
A composition comprising:
- (a) an antigen;
- (b) an adjuvant;
- (c) at least one carrier comprising a member selected from the groups consisting of:
- (i) an acylated amino acid or a salt thereof;
- (ii) a poly amino acid comprising at least one acylated amino acid or a salt thereof;
- (iii) a sulfonated amino acid or a salt thereof;
- (iv) a poly amino acid comprising at least one sulfonated amino acid or a salt thereof;
- or
- (v) any combination thereof.
6 more elements
A composition comprising:
- (a) ovalbumin;
- (b) cholera toxin;
- and
- (c) at least one carrier comprising a member selected from the groups consisting of:
- (i) an acylated amino acid or a salt thereof;
- (ii) a poly amino acid comprising at least one acylated amino acid or a salt thereof;
- (iii) a sulfonated amino acid or a salt thereof;
- (iv) a poly amino acid comprising at least one sulfonated amino acid or a salt thereof;
- or
- (v) any combination thereof.
7 more elements
A composition comprising:
- (a) Infectious Bursal Disease Virus;
- (b) cholera toxin;
- (c) cholera toxin β-subunit;
- and
- (d) at least one carrier comprising a member selected from the groups consisting of:
- (i) an acylated amino acid or a salt thereof;
- (ii) a poly amino acid comprising at least one acylated amino acid or a salt thereof;
- (iii) a sulfonated amino acid or a salt thereof;
- (iv) a poly amino acid comprising at least one sulfonated amino acid or a salt thereof;
- or
- (v) any combination thereof.
8 more elements
A method for preparing microspheres, said method comprising:
- (A) solubilizing, in a solvent, at least one carrier to provide a carrier solution;
- and
- (B) contacting said carrier solution with an antigen, an adjuvant, and a precipitator solution in which said carrier is insoluble;
- wherein said carrier comprises a member selected from the groups consisting of:
- (a) an acylated amino acid or a salt thereof;
- (b) a poly amino acid comprising at least one acylated amino acid or a salt thereof;
- (c) a sulfonated amino acid or a salt thereof;
- (d) a poly amino acid comprising at least one sulfonated amino acid or a salt thereof;
- or
- (e) any combination thereof.
7 more elements
Dependencies are inferred from the claim text.