Targeting of organs by immunoconjugates
OwnerAkhouri A. Sinhainventor
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Abstract
Bioactive materials, e.g. therapeutic agents for treating a condition that afflicts a patient, are delivered to the afflicted organ in a site-specific manner by coupling the bioactive agent to an antibody or fragment or derivative thereof that recognizes a substance unique to that organ. For example, therapeutic agents for treating conditions of the prostate gland such as adenocarcinoma of the prostate, benign prostatic hypertrophy and prostatitis can be delivered to the prostate by coupling the thereapeutic agent to an antibody against a substance secreted by the prostate, e.g. prostatic specific antigen or prostatic acid phosphatase.
Claims15
An immunoconjugate that recognizes a substance unique to an organ, comprising an antibody or derivative or fragment thereof for said substance, linked to a bioactive agent.
A method of delivering a bioactive substance to an organ in an animal, comprising administering to the animal an immunoconjugate which comprises an antibody or derivative or fragment thereof for a substance which is unique to the organ, and a bioactive agent linked to the antibody or derivative or fragment thereof.
Dependencies are inferred from the claim text.