Apparatus and methods for evaluating the quality of a combinatorial library of compounds
OwnerFrank R. Holden, William L. Fitch +1inventors
InventorsFrank R. Holden, William L. Fitch, Kenneth C. Lewis
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Abstract
Devices and methods are provided to facilitate the evaluation of the quality of a combinatorial library of compounds. One exemplary device comprises a holding plate having an array of apertures. A plurality of vials are removably held within the apertures. Each of the vials has an open top end. A seal member is disposed over the top ends of the vials, and a top plate is removably coupled to the holding plate to force the seal member against the top ends of the vials.
Claims20
A device to evaluate the quality of a combinatorial library of compounds, the device comprising:
- a holding plate having an array of apertures;
- a plurality of vials removably held within the apertures, the vials having open top ends;
- a seal member disposed over the top ends of the vials;
- and
- a top plate removably coupled to the holding plate to force the seal member against the top ends of the vials.
A method for evaluating the quality of a combinatorial library of compounds, the method comprising:
- providing a device comprising a holding plate and a plurality of vials held by the holding plate;
- placing at least one solid support into at least some of the vials, the solid support each having a ligand and encoded tags;
- sealing the solid supports in the vials;
- cleaving the ligand from the solid supports;
- removing a ligand sample from the vials;
- cleaving the encoded tags from the solid supports, wherein the vials are heating during cleavage while the solid supports are sealed within the vials;
- removing samples of the cleaved tags from the vials;
- and
- comparing the ligand to a structure indicated by the tags for each solid support.
Dependencies are inferred from the claim text.