Copolymers and blood filter using the same
OwnerMasaru Tanaka, Norifumi Tokunagainventors
Life of this patent
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Abstract
A copolymer having excellent blood compatibility comprising an alkoxyalkyl (meth)acrylate and a comonomer having a basic functional group, a surface treating agent for blood filter using the same, and blood filter coated with the same on the surface thereof. The copolymer is useful as blood filter material for efficiently removing leucocytes and platelets while preventing damages of blood components at the time of blood filtration to a low level.
Claims11
A copolymer comprising a monomer represented by formula A and at least one comonomer selected from the group consisting of copolymers represented by formulae B, C, D and E.
- 6
- (wherein R1 is an alkylene group having 1 to 4 carbon atoms, R2 is an alkyl group having 1 to 4 carbon atoms, and R3 independently represents hydrogen or a methyl group in each formula)
- 7
- (wherein R4 and R5 independently represent hydrogen or an alkyl group having 1 to 4 carbon atoms in each formula, n is an integer in each formula, and R3 is as defined above)
- 8
- (wherein R3, R4, R5 and n are as defined above)
- 9
- (wherein R3, R4 and R5 are as defined above, R6 independently represents hydrogen or an alkyl group having 1 to 4 carbon atoms in each formula, n is as defined above, and X− independently represents a halogen ion, sulfonic ion or hydrogen sulfate ion)
- 10
- (R3, R4, R5, and R6 are as defined above, n is as defined above, and X− is as defined above).
A blood filter unit comprising a filter material having on the surface thereof a copolymer comprising a monomer represented by formula A
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- (wherein R1 is an alkylene group having 1 to 4 carbon atoms, R2 is an alkyl group having 1 to 4 carbon atoms, and R3 independently represents hydrogen or a methyl group in each formula) and at least one comonomer selected from the group consisting of aminostyrene, N,N-dimethylaminostyrene, N,N-diethylaminostyrene, vinylpyridine, N-methyl-N-vinylpyridine, N-ethyl-N-vinylpyridine, vinylquinoline, ethyleneimine, propyleneimine, N-aminoethylethyleneimine, vinylimidazole, vinylpyrazoline, and vinylpyrazine.
A blood filter unit obtained by treating a copolymer comprising a monomer represented by formula A
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- (wherein R1 is an alkylene group having 1 to 4 carbon atoms, R2 is an alkyl group having 1 to 4 carbon atoms, and R3 independently represents hydrogen or a methyl group in each formula) and at least one comonomer selected from the group consisting of aminostyrene, N,N-dimethylaminostyrene, N,N-diethylaminostyrene, vinylpyridine, N-methyl-N-vinylpyridine, N-ethyl-N-vinylpyridine, vinylquinoline, ethyleneimine, propyleneimine, N-aminoethylethyleneimine, vinylimidazole, vinylpyrazoline, and vinylpyrazine, with an alkyl halide or an alkyl sulfate to convert it to a quaternary ammonium salt and then coating a surface of a filter material with the salt.
Dependencies are inferred from the claim text.