Use for 1,3-propanediol derivatives
AssigneeNovartis AG
InventorsSylvain Cottens, Robert P. Hof, Roland Wenger
Life of this patent
Estimating the term…
Abstract
Use of a compound of formula I 1 wherein R1 is an optionally substituted straight- or branched carbon chain having 12 to 22 carbon atoms which may be optionally interrupted by an optionally substituted phenylene, and each of R2, R3, R4 and R5, independently, is H or lower alkyl, in free form or in pharmaceutically acceptable salt form, in the prevention or treatment of chronic rejection in a recipient of organ or tissue allo- or xenotransplant, or of acute rejection in a xenograft transplant recipient.
Claims10
Use of a compound of formula I
- 3
- wherein
- R1 is an optionally substituted straight- or branched carbon chain having 12 to 22 carbon atoms which may be optionally interrupted by an optionally substituted phenylene, and
- each of R2, R3, R4 and R5, independently, is H or lower alkyl,
- in free form or in pharmaceutically acceptable salt form,
- in the preparation of a pharmaceutical composition for preventing or treating manifestations of chronic rejection in a recipient of organ or tissue allo- or xenotransplant.
Use of a compound of formula I
- 4
- wherein
- R1 is an optionally substituted straight- or branched carbon chain having 12 to 22 carbon atoms which may be optionally interrupted by an optionally substituted phenylene, and
- each of R2, R3, R4 and R5, independently, is H or lower alkyl,
- in free form or in pharmaceutically acceptable salt form,
- in the preparation of a pharmaceutical composition for preventing or treating graft vessel diseases in a recipient of organ or tissue allo- or xenotransplant.
Use of a compound of formula I
- 5
- wherein
- R1 is an optionally substituted straight- or branched carbon chain having 12 to 22 carbon atoms which may be optionally interrupted by an optionally substituted phenylene, and
- each of R2, R3, R4 and R5, independently, is H or lower alkyl,
- in free form or in pharmaceutically acceptable salt form,
- in the preparation of a pharmaceutical composition for preventing or controlling acute rejection in a xenograft transplant recipient.
Use according to any one of the preceding claims, wherein the compound of formula I is 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol, in free form or in pharmaceutically acceptable salt form.
A kit or package for preventing or treating manifestations of chronic rejection in a recipient of organ or tissue allo- or xenotransplant, or for preventing or controlling acute rejection in a xenograft transplant recipient, comprising a compound of formula I, in free form or in a pharmaceutically acceptable salt form, with a pharmaceutical composition comprising an immunosuppressant or immunomodulatory drug.
Dependencies are inferred from the claim text.