Synthetic compounds for treatment of inflammation
AssigneesHarbor Branch Oceanographic Instutition, Inc., The Regents of the University of California
InventorsAmy E. Wright, Ralph-Heiko Mattern, Robert S. Jacobs
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Abstract
Novel uses of biologically active bis-heterocyclic e.g. bis-indole alkaloid compounds which have improved activity are disclosed. Pharmaceutical compositions containing the compounds are also disclosed. Specifically, the novel utility pertains to the anti-immunogenic and neurogenic inflammatory properties exhibited by the bis-indole compounds and their analogs.
Claims29
A method of treating inflammation in a human or animal, wherein said method comprises administering to said human or animal an effective amount of a compound having the following structure:
- 4
- wherein R1-10 are the same or different and are selected from the group consisting of —H, —OH, halogen, —COOH, —COOR, C1-C8 alkyl, C1-C8 alkoxyl, mesyl, tosyl, —OCOR, and NZ1Z2 (wherein the Zs can be the same or different);
- X1 and X2 are the same or different and are selected from the group consisting of —H, —R, —COY, and C(NZ1)Y;
- Y is —H, —OH, NZ1Z2 (wherein the Z1 and Z2 can be the same or different) C1-C8 alkyl, C1-C8 alkoxyl or an amino acid linked through the amine functionality forming an amide bond;
- Z1 and Z2 are the same or different and are selected from the group consisting of —H, —OH, C1-C8 alkyl, C1-C8 alkoxyl and —COR;
- and R is C1-C8 alkyl, or aryl.
A composition specifically adapted for use in treating inflammation wherein said composition comprises a compound having the following structure:
- 5
- wherein R1-10 are the same or different and are selected from the group consisting of —H, —OH, halogen, —COOH, —COOR, C1-C8 alkyl, C1-C8 alkoxyl, mesyl, tosyl, —OCOR, and NZ1Z2 (wherein the Zs can be the same or different);
- X1 and X2 are the same or different and are selected from the group consisting of —H, —R, —COY, and C(NZ1)Y;
- Y is —H, —OH, NZ1Z2 (wherein the Z1 and Z2 can be the same or different) C1-C8 alkyl, C1-C8 alkoxyl or an amino acid linked through the amine functionality forming an amide bond;
- Z1 and Z2 are the same or different and are selected from the group consisting of —H, —OH, C1-C8 alkyl, C1-C8 alkoxyl and —COR;
- and
- R is C1-C8 alkyl, or aryl.
A method for treating a condition, in a human or animal, wherein said condition is selected from the group consisting of pain;
- burns;
- allergic responses;
- rheumatoid arthritis;
- osteoarthritis;
- other inflammatory conditions involving acute joint inflammation, chronic joint inflammation, or both;
- wound healing;
- anaphylactic reactions;
- inflammatory bowel disease;
- nephritis;
- conjunctivitis;
- inflammatory gum disease;
- acute asthmatic attack and inflammation of the lung due to chemical exposure, said method comprising administering an effective amount of a bis-heterocyclic compound or a salt, analog, or derivative thereof, wherein said compound has the following structure:
- 6
- wherein R1-R10 are the same or different and are selected from the group consisting of —H, —OH, halogen, —COOH, —COOR, C1-C8 alkyl, C1-C8 alkoxyl, mesyl, tosyl, —OCOR, and NZ1Z2 (wherein the Zs can be the same or different);
- X1 and X2 are the same or different and are selected from the group consisting of —H, —R, —COY, and C(NZ1)Y;
- Y is —H, —OH, NZ1Z2 (wherein the Z1 and Z2 can be the same or different) C1-C8 alkyl, C1-C8 alkoxyl or an amino acid linked through the amine functionality forming an amide bond;
- Z1 and Z2 are the same or different and are selected from the group consisting of —H, —OH, C1-C8 alkyl, C1-C8 alkoxyl and —COR;
- and
- R is C1-C8 alkyl, or aryl.
Dependencies are inferred from the claim text.