Diaminocyclobutene-3,4-dione derivatives, their preparation and use

A compound having the formula

• 13
• or a pharmaceutically acceptable salt thereof
• wherein
• X represents
• 14
• Y represents O or S;
• R′ and R′″ represents hydrogen, halogen, alkyl, alkoxy, aryl, CF3, OCF3;
• R″ represents hydrogen, halogen, CF3, NO2, alkyl, alkoxy, aryl or a 5- or 6-membered monocyclic heterocyclic group optionally substituted with halogen, alkyl, OH, alkoxy, NO2, amino, aminocarbonyl or CF3;
• R2 represents OH, CH2CO2H, a cyclic or heterocyclic acidic functional group optionally substituted with alkyl or aryl, or
• 15
• wherein Z represents OH, alkoxy, NR9R10 wherein R9 and R10 independently represents hydrogen, alkyl, cycloalkyl, alkylcycloalkyl, aryl, heteroaryl, a 5- to 7 membered cyclic group optionally containing one or two heteroatoms, SO2-R11 wherein R11 is hydrogen, alkyl or aryl;
• or R9 and R10 together represents a 5 to 7 membered cyclic group optionally containing one heteroatom;
• NR11R12 wherein R11 and R12 independently represents hydrogen, alkyl, cycloalkyl, alkylcycloalkyl, aryl, SO2-R13 wherein R13 is hydrogen, alkyl or aryl;
• or
• R11 and R12 together represents a 5 to 7 membered cyclic group optionally containing one heteroatom;
• SO2-R13 wherein R13 is hydrogen, alkyl, aryl, NR14R15 wherein R14 and R15 independently represents hydrogen, alkyl, cycloalkyl, alkylcycloalkyl or aryl;
• or R14 and R15 together represents a 5 to 7 membered cyclic group optionally containing one heteroatom;
• R3 represents hydrogen, alkyl, halogen, CF3, OCF3 or NO2;
• R4 represents hydrogen, halogen, alkyl, OH, SO2N(alkyl)2, alkoxy, NO2, amino or aryl optionally substituted with
• 16
• wherein
• Z represents OH, alkyl, alkoxy, NO2, CF3, OCF3, NHR16R17 wherein R16 and R17 independently represents hydrogen, alkyl, cycloalkyl, alkylcycloalkyl, aryl, heteroaryl, a 5- to 7 membered cyclic group optionally containing one or two heteroatoms;
• or R16 and R17 together represents a 5 to 7 membered cyclic group optionally containing one heteroatom;
• alkoxy, OH or SO2-R18 wherein R18 is hydrogen, alkyl, aryl, NR19R20 wherein R19 and R20 independently represents hydrogen, alkyl, cycloalkyl, alkylcycloalkyl or aryl;
• or R19and R20 together represents a 5 to 7 membered cyclic group optionally containing one heteroatom;
• NR21R22 wherein R21 and R22 independently represents hydrogen, alkyl, cycloalkyl, alkylcycloalkyl, aryl, heteroaryl, a 5- to 7 membered cyclic group optionally containing one or two heteroatoms;
• or R21 and R22 together represents
• a 5 to 7 membered cyclic group optionally containing one heteroatom;
• or
• 17
• wherein Z represents alkyl, aryl or SO2-R23 wherein R23 is hydrogen, alkyl or aryl;
• a 5- or 6-membered monocyclic heterocyclic group optionally substituted with halogen, alkyl, OH, alkoxy, NO2, amino, aminocarbonyl or CF3;
• R5 represents hydrogen, halogen, NO2, alkyl, alkoxy, CF3 or OCF3;
• R6 represents hydrogen, alkyl, alkoxy, OCF3, CF3 or NO2;
• R7 and R8 independently represents hydrogen or alkyl.