Composition comprising camptothecin or a camptothecin derivative and an alkylating agent for the treatment of cancer
AssigneeAventis Pharma S.A.
InventorMarie-Christine Bissery
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Abstract
The present invention relates to therapeutic associations for the treatment of cancer, comprising an effective amount of a camptothecin, or a camptothecin derivative, with an effective amount of an alkylating agent, such as melphalan, dacarbazine, or cyclophosphamide, and methods of using such therapeutic associations.
Claims15
A therapeutic pharmaceutical composition, comprising an effective amount of camptothecin, or a camptothecin derivative, in combination with an effective amount of an alkylating agent for the treatment of solid tumors.
A therapeutic pharmaceutical composition, comprising an effective amount of CPT-11, in combination with an effective amount of an alkylating agent for the treatment of solid tumors.
A synergistic therapeutic pharmaceutical composition, comprising an effective amount at least two agents, wherein at least one agent is CPT-11, in combination with an effective amount of at least one second agent, wherein said second agent is cyclophosphamide, for the treatment of solid tumors.
A method of treating solid tumors, comprising administering orally an effective amount of camptothecin, or a camptothecin derivative, as a first agent, in combination with intravenous administration of an effective amount of an alkylating agent as a second agent.
A method of therapeutic administration of an anti-solid tumor composition, comprising an effective amount of camptothecin, or a camptothecin derivative, in combination with an effective amount of an alkylating agent for the treatment of solid tumors, wherein said administration of the effective amounts is separate or together, and is simultaneous, semi-simultaneous, or is spaced out over a period of time.
Dependencies are inferred from the claim text.