Novel lipophilic compounds having affinity with nucleic acids and therapeutical uses thereof

A compound of the general formula (I) below:

• 11
• Wherein A is a phosphorus or an arsenic atom;
• X− is an anion;
• and
• wherein R1 is selected from the group consisting of:
• a) the radical of formula (II) below:
• 12
• wherein R5 represents a lipid moiety and R6 is a linear or branched alkyl chain from 1 to 4 carbon atoms,
• Provided that R2, R3 and R4 of formula (I) represent each a methyl group;
• b) the radical of formula (III) below:
• 13
• wherein R5 represents a lipid moiety and R6 is a linear or branched alkyl chain from 1 to 4 carbon atoms,
• provided that R2, R3 and R4 of formula (I) represent each a methyl group;
• c) the radical of formula (IV) below:
• 14
• wherein Chol means a cholesteryl radical and R6 is a linear or branched alkyl chain from 1 to 4 carbon atoms,
• provided that R2 and R3 of formula (I) represent each a methyl group;
• and
• d) the radical of formula (V) below:
• 15
• wherein R5 represents a lipid moiety and R6 is a linear or branched alkyl chain from 1 to 4 carbon atoms,
• provided that R2 and R4 are alkyl chains from 1 to 4 carbon atoms;
• and
• R3 is selected from the group consisting of:
• an alkyl chain as defined for R2 and R4,
• the functional group CH2—CH2—P+ (R6R7R8), wherein R6, R7 and R8 have the same meaning as R2 and R4;
• and
• —CH2—CO2R9, wherein R9 has the same meaning as R2.