Gene therapy method for revascularizing ischemic tissue
OwnerAscher Shmulewitz, Jerry Sandersinventors
Life of this patent
Estimating the term…
Abstract
There is disclosed a method for optimizing revascularizing ischemic tissue, particularly ischemic myocardial tissue. Specifically, there is disclosed a means for retrograde perfusion of angiogenic gene therapy vectors to ischemic tissue, wherein the polypeptide(s) encoded by the gene therapy vectors promote angiogenesis and neovascularization, and are selected from the group consisting of VEGF, ICAM-1, FGF, EGF, nitric acid synthase (NOS), E-selectin, and combinations thereof.
Claims7
A method for revascularizing ischemic tissue or improving the vascular flow of ischemic tissue, comprising administering an angiogenesis inducing gene encoding an angiogenesis growth factor encapsulated in a liposomal carrier vehicle into the ischemic tissue.
Dependencies are inferred from the claim text.