Method to identify a surface-bound molecule
AssigneeThe Penn State Research Foundation
InventorsNICHOLAS WINOGRAD, DONALD E. RIEDERER, REEMA CHATTERJEE
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Abstract
The present invention relates to a method of identifying a molecule of a molecule-substrate complex, wherein the molecule is covalently attached directly to a substrate or indirectly by means of a linking moiety, comprising: (a) bombarding the molecule-substrate complex with energized particles to cleave the molecule from the molecule-substrate complex; and (b) determining the molecular weight of the cleaved molecule by means of mass spectrometry. The inventive method may further comprise irradiating the cleaved molecule with photons.
Claims21
A method of identifying a molecule of a molecule-substrate complex, wherein the molecule is covalently attached directly to a substrate or indirectly by means of a linking moiety, comprising:
- (a) bombarding the molecule-substrate complex with energized particles to cleave the molecule from the molecule-substrate complex;
- and
- (b) determining the molecular weight of the cleaved molecule by means of mass spectrometry.
Dependencies are inferred from the claim text.