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AssigneeRiken
InventorsFumio Nakamura, Masahiko Hara
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A substrate for detecting base sequences that comprises a transparent support, a thin metal film formed on one side of the transparent support, and a self-assembled monolayer with a nonionic aromatic compound being an intercalator of nucleic acid polymers dispersed over the surface formed on the metal film. The substrate is manufactured, for example, by immersing a transparent support with a thin gold film formed on one side in a solution that contains a disulfide (S—S) compound containing anthracene for the intercalator of nucleic acid polymers form on the metal film. A nucleic acid polymer (probe or target) is immobilized to the monolayer of the substrate, another nucleic acid polymer (target or probe) is hybridized to the nucleic acid polymer immobilized to the monolayer, and the results of the hybridization can be detected by the Surface Plasmon Resonance method after washing.
A substrate for detecting base sequences that comprises a transparent support, a thin metal film formed on one side of the transparent support, and a self-assembled monolayer with a nonionic aromatic compound being an intercalator of nucleic acid polymers dispersed over the surface formed on the metal film.
A method of manufacturing a substrate for detecting base sequences, characterized by comprising the following steps:
A substrate for detecting base sequences, characterized by having a self-assembled monolayer of a disulfide containing anthracene being an intercalator of nucleic acid polymers.
A method of manufacturing the substrate for detecting base sequences, characterized by comprising the following steps:
The substrate for detecting base sequences, characterized by having a self-assembled monolayer of a thiol containing pyrene being an intercalator of nucleic acid polymers.
A method of manufacturing a substrate for detecting base sequences, characterized by comprising the following steps:
Dependencies are inferred from the claim text.