Use of rapamycin and agents that inhibit B7 activity in immunomodulation
OwnerJoseph Sypek, Mark J. Collinsinventors
Life of this patent
Estimating the term…
Abstract
The invention provides methods for downmodulating an immune response comprising contacting immune cells from a subject with at least one agent that binds to at least one B7 molecule in combination with a Rapamycin compound.
Claims13
A method for downmodulating an immune response comprising contacting immune cells from a subject with at least one antibody that binds to at least one B7 molecule in combination with a Rapamycin compound.
A method for downmodulating an immune response in a subject having an autoimmune disorder comprising contacting immune cells from the subject with at least one antibody that binds to at least one B7 molecule in combination with a Rapamycin compound.
A method for downmodulating an immune response in a subject suffering from systemic lupus erythematosis comprising administering to the subject an antibody that binds to B7-1, an antibody that binds to B7-2, and a Rapamycin compound, wherein the antibody that binds to B7-1 and the antibody that binds to B7-2 are administered over at least one short course of therapy.
A method for downmodulating an immune response in a subject suffering from systemic lupus erythematosis comprising administering to the subject an antibody that binds to B7-1, an antibody that binds to B7-2, and a Rapamycin compound, wherein the Rapamycin compound is administered over at least one intermediate course of therapy.
A method for downmodulating an immune response in a subject suffering from systemic lupus erythematosis comprising administering to said subject an antibody that binds B7-1, an antibody that binds B7-2, and a Rapamycin compound, wherein said Rapamycin compound is administered over at least one extended course of therapy.
A method for downmodulating an immune response in a subject suffering from systemic lupus erythematosis comprising administering to said subject an antibody that binds B7-1, an antibody that binds B7-2, and a Rapamycin compound, wherein said Rapamycin compound is administered according to an early dosing regimen.
A method for downmodulating an immune response in a subject suffering from systemic lupus erythematosis comprising administering to said subject an antibody that binds B7-1, an antibody that binds B7-2, and a Rapamycin compound, wherein said Rapamycin compound is administered according to a late dosing regimen.
A method for downmodulating an immune response in a subject suffering from systemic lupus erythematosis comprising administering to said subject an antibody that binds B7-1, an antibody that binds B7-2, a Rapamycin compound, and an immunosupressing agents, wherein said immunosupressing agent is selected from the group consisting of FK506, Cyclosporin A and cyclophosphamide.
Dependencies are inferred from the claim text.