Methods of preventing aggregation of various substances upon rehydration or thawing and compositions obtained thereby
AssigneeElan Drug Delivery Limited
InventorsBruce J. Roser, Camilo Colaco, Jaap Kampinga, Christopher Smith
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Abstract
The present invention encompasses methods to prevent aggregation of a wide variety of substances during freezing/thawing and/or dehydrating/rehydrating. The substances thus obtained and compositions comprising the substances are also encompassed by the invention.
Claims42
A method of reducing aggregation during dehydration and rehydration of substances comprising the steps of
- adding to a solution or suspension of the substances an amount of trehalose sufficient to prevent aggregation upon rehydration;
- and
- dehydrating the solution or suspension.
A method of reducing aggregation of substances in solution or suspension during freezing comprising the steps of:
- adding to the solution or suspension of the substance an amount of trehalose sufficient to prevent aggregation during freezing;
- and
- freezing the solution or suspension.
An aqueous composition comprising a substance and an amount of trehalose sufficient to prevent substantial aggregation of the substance upon freezing and thawing or dehydrating and rehydrating.
A frozen composition comprising a substance and an amount of trehalose sufficient to prevent substantial aggregation of the substance upon thawing.
A dehydrated composition comprising a substance and an amount of trehalose sufficient to prevent aggregation of the substance upon rehydration.
Dependencies are inferred from the claim text.