Delivery systems for active ingredients including sunscreen actives and methods of making same
AssigneeShamrock Technologies, Inc.
InventorsDouglas S. Deblasi, Manshi Sui, Roy Pe
Life of this patent
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Abstract
The present invention provides methods of making delivery systems for active ingredients including hydrogenated jojoba and sunscreen actives. The recrystallization process of the present invention produces small particle size alloys from molten mixtures and recrystallized small particle size dispersions from high temperature solvent solutions. The invention further provides delivery systems for active ingredients such as sunscreen actives.
Claims36
A method of making a delivery system for at least one solid or liquid organic sunscreen active, said method comprising the steps of:
- (a) selecting at least one solid organic wax lubricant that is miscible with said at least one sunscreen active at a temperature within a range of from about 70° C. to about 150° C.;
- (b) heating said at least one solid organic wax lubricant to a temperature within said range to form a liquid;
- (c) simultaneous with said heating or subsequent thereto, adding said at least one sunscreen active with stirring while maintaining the temperature of said liquid within said temperature range;
- (d) cooling said liquid to form a substantially solid mixture;
- and
- (e) milling said solid mixture to form a powder mixture comprising crystals of said at least one solid sunscreen active or droplets of said at least one liquid sunscreen active and crystals of said at least one organic wax lubricant.
A method of making a delivery system for at least one inorganic sunscreen active, said method comprising the steps of:
- (a) selecting at least one solid organic wax lubricant;
- (b) heating said at least one solid organic wax lubricant to a temperature within a range of from about 100° C. to about 175° C. to form a liquid;
- (c) adding said at least one inorganic sunscreen active with stirring while maintaining the temperature of said liquid within said temperature range;
- (d) cooling said liquid to form a substantially solid dispersion;
- and
- (e) milling said solid dispersion to form a powder comprising crystals of said at least one sunscreen active and crystals of said at least one organic wax lubricant.
A method of making a delivery system for at least one inorganic sunscreen active, said method comprising the steps of:
- (a) selecting at least one solid organic was lubricant and at least one liquid solvent;
- (b) heating said at least one solid organic wax lubricant and said at least one liquid solvent with stirring to a temperature within a range of from about 100° C. to about 175° C. to form a solution;
- (c) adding at least one inorganic sunscreen active with stirring while maintaining the temperature within said temperature range to form a liquid dispersion;
- and
- (d) cooling said liquid dispersion.
A method of making a delivery system for at least one solid or liquid organic sunscreen active, said method comprising the steps of:
- (a) selecting at least one liquid solvent in which said at least one sunscreen active is not readily soluble alone;
- (b) selecting at least one solid organic wax lubricant that is capable of functioning as a cosolvent to enable said at least one sunscreen active to be dissolved readily in said at least one solvent at a temperature within a range of from about 70° C. to about 175° C.;
- (c) heating said at least one solid organic wax lubricant in the presence of said at least one solvent with stirring to a temperature within said range to form a solution;
- (d) simultaneously with said heating or subsequent thereto, adding said at least one sunscreen active to said solution with stirring while maintaining the temperature of said solution within said range;
- and
- (e) cooling said solution rapidly while stirring to form a powder dispersion comprising crystals of said at least one solid organic sunscreen active or droplets of said at least one liquid organic sunscreen active and crystals of said at least one organic wax lubricant in said at least one solvent.
A method for forming a recrystallized powder dispersion of at least one organic solid, said method comprising the steps of:
- (a) dissolving said at least one organic solid in at least one liquid solvent by heating and stirring to form a liquid solution thereof;
- (b) dispersing in said liquid solution with stirring at least one nucleating agent selected from the group consisting of titanium dioxide, zinc oxide, talc, mica, boron nitride, polytetrafluoroethylene, polypropylene, hollow microencapsulation beads and nylon microspheres;
- and
- (c) cooling said liquid solution while stirring to form a powder dispersion comprising crystals of said at least one organic solid in said at least one solvent, whereby the average size of the particles formed within said dispersion by the crystals of said at least one organic solid is substantially reduced as compared with the average size of the particles of said at least one organic solid prior to said dissolving step.
A delivery system for at least one sunscreen active consisting of a powder mixture comprising said at least one sunscreen active and crystals of at least one organic wax lubricant.
A delivery system for at least one organic sunscreen active consisting of a powder dispersion comprising said at least one organic sunscreen active dispersed in at least one liquid solvent in which said at least one sunscreen active is not readily soluble alone, said powder dispersion further comprising crystals of at least one organic wax lubricant, said at least one lubricant being capable of functioning as a cosolvent to enable said at least one sunscreen active to be dissolved readily in said at least one solvent at an elevated temperature range.
A delivery system for at least one inorganic sunscreen active consisting of a dispersion comprising crystals of at least one organic wax lubricant dispersed in at least one liquid solvent, said crystals of said at least one organic wax lubricant having embedded therewithin crystals of said at least one sunscreen active.
Dependencies are inferred from the claim text.