Decellularized vascular prostheses resistant to thrombus occlusion and immunologic rejection
AssigneeBaylor College of Medicine
InventorsChangyi Chen, Alan B. Lumsden
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Abstract
The present invention relates to decellularized vascular prostheses that are resistant to thrombus occlusion and have a low level of immunogenicity. The vascular prostheses are denuded of cells, and coated with an anti-thrombogenic agent and a growth factor that promotes recellularization and further reduces the immunogenicity. The prostheses have high mechanical strength, resist aneurysm rupture, and allow for secure surgical sutures while maintaining structural integrity. The present invention provides vascular prostheses that are blood vessels, valves or portions of vessels containing valves. The present invention is also useful for coating synthetic vascular stents.
Claims29
A vascular prosthesis comprising a decellularized vascular tissue linked with an anti-thrombogenic compound and a growth factor.
A method of preparing a decellularized vascular prosthesis comprising the steps of:
- a) obtaining a vascular tissue from a human or an animal;
- b) decellularizing the vascular tissue;
- c) covalently linking the decellularized vascular tissue with an anti-thrombogenic compound;
- and
- d) linking the decellularized vascular tissue with a growth factor.
A method of linking a heparanized and decellularized vascular tissue to a growth factor, comprising the steps of:
- a) washing the heparinized and decellularized vascular tissue;
- and
- b) binding the heparanized and decellularized vascular tissue to a growth factor.
Dependencies are inferred from the claim text.