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US 2001/0044584 A1Published application
In vivo delivery methods and compositions
OwnerKenneth R. Kenseyinventor
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OwnerKenneth R. Kenseyinventor
Estimating the term…
Various methods are provided for determining and utilizing the viscosity of the circulating blood of a living being over a range of shear rates for diagnostics and treatment, such as detecting/reducing blood viscosity, work of the heart, contractility of the heart, for detecting/reducing the surface tension of the blood, for detecting plasma viscosity, for explaining/countering endothelial cell dysfunction, for providing high and low blood vessel wall shear stress data, red blood cell deformability data, lubricity of blood, and for treating different ailments such as peripheral arterial disease in combination with administering to a living being at least one pharmaceutically acceptable agent. Agents pharmaceutically effective to regulate at least one of the aforementioned blood parameters are used to adjust distribution of a substance through the bloodstream.
A method to distribute a substance through a bloodstream of an organism, said method comprising:
In a method for distributing a substance through a circulatory system to at least one target in an organism, the improvement wherein at least one blood flow parameter selected from the group consisting of circulating blood viscosity, absolute viscosity, effective viscosity, low shear viscosity, high shear viscosity, shear rate of circulating blood, work of heart, contractility of heart, thrombogenicity, platelet aggregation, lubricity, red blood cell deformability, thixotropy, yield stress, coagulability, coagulation time, agglutination, clot retraction, clot lysis time, sedimentation rate and prothrombin rate is monitored and altered to control said distributing.
A composition for administration to an organism having a circulatory system, said composition comprising:
Dependencies are inferred from the claim text.