Transition metal-catalyzed reactions based on chiral amine oxazolinyl ligands
AssigneeThe Penn State Research Foundation
InventorXumu Zhang
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Abstract
The invention is drawn to novel transition metal catalysts for the practical synthesis of important chiral molecules. The transition metal catalysts comprise chiral ligands based on chiral amine oxazolinyl ligands. The invention includes methods of making the catalysts, and methods of performing reactions using the catalysts.
Claims20
A chiral ligand that forms a catalyst providing enhanced enantiomeric selectivity in asymmetric reactions, having a structure selected from the group consisting of the enantiomers of the following formulas (I) through (IV):
- 12
- wherein R1, R2, R3, R4, R5, R6 and R7 are independently hydrogen, alkyl, aryl, substituted alkyl or substituted aryl, wherein any two of R1, R2, R3 and R4 may be linked to each other to form a ring structure, wherein any two of R5, R6 or R7 may be linked to each other to form a ring structure, and wherein n is 1 or 2.
A chiral ligand that forms a catalyst providing enhanced enantiomeric selectivity in asymmetric reactions, said chiral ligand comprising a bis(oxazolinyl) amine.
Dependencies are inferred from the claim text.