Novel FGF Homolog zFGF12
OwnerDarrell C. Conklininventor
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Abstract
The present invention relates to polynucleotide and polypeptide molecules for zFGF12 a novel member of the FGF family. The present invention also includes antibodies to the zFGF12 polypeptides, and methods of using the polynucleotides and polypeptides.
Claims18
An isolated polypeptide comprising a sequence of amino acid residues that is at least 95% identical to the sequence as shown in SEQ ID NO:2 from residue 25 through residue 251.
An isolated polypeptide comprising a sequence of amino acid residues as shown in SEQ ID NO:2 from amino acid residue 25 to amino acid residue 251.
An isolated polypeptide comprising at least 15 contiguous amino acid residues of SEQ ID NO:2.
An isolated polynucleotide molecule comprising a sequence of nucleotides that encode for a sequence of amino acid residues that is at least 95% identical to the sequence as shown in SEQ ID NO:2 from residue 25 through residue 251.
An isolated polynucleotide molecule comprising a sequence of nucleotides that encode for a sequence of amino acid residues as shown in SEQ ID NO:2 from amino acid residue 25 to amino acid residue 251.
An isolated polynucleotide molecule comprising a sequence of nucleotides as shown in SEQ ID NO:1 from nucleotide 187 to nucleotide 870 or SEQ ID NO:3 from nucleotide 72 to nucleotide 753.
A method of stimulating proliferation of mesenchymal cells comprising culturing mesenchymal stem cells or progenitor cells in the presence of zFGF12 polypeptide comprising a sequence of amino acid residues as shown in SEQ ID NO:2 from amino acid residue 25 to amino acid residue 251, in an amount sufficient to increase the number of mesenchymal cells as compared to cells grown in the absence of zFGF12 polypeptide.
Dependencies are inferred from the claim text.