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US 2001/0044519 A1Published application
Process for removing bile salts from a patient and alkylated compositions therefor
AssigneeGelTex Pharmaceuticals, Inc.
InventorsW. Harry Mandeville, III, Stephen Randall Holmes-Farley
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Abstract
The invention relates to a method for removing bile salts from a patient in need thereof and compositions useful in the method. The method comprises administering to the patient a therapeutically effective amount of a salt of an alkylated and crosslinked polymer. The alkylated and crosslinked polymer salt comprises the reaction product of crosslinked polymers, or salts and copolymers thereof having amine containing repeat units, with at least one aliphatic alkylating agent.
Claims12
The salt of an alkylated and crosslinked polymer comprising the reaction product of:
- (a) one or more crosslinked polymers, or salts and copolymers thereof having a repeat unit selected from the group consisting of:
- 3 (NR—CH2CH2)n (2) and (NR—CH2CH2—NR—CH2CH2—NR—CH2CHOH—CH2)n (3)
- where n is a positive integer and each R, independently, is H or a C1-C8 alkyl group;
- (b) at least one aliphatic alkylating agent, said reaction product characterized in that:
- (i) at least some of the nitrogen atoms in said repeat units unreacted with said alkylating agent;
- (ii) less than 10 mol % of the nitrogen atoms in said repeat units reacting with said alkylating agent forming quaternary ammonium units;
- and
- (iii) a fixed positive charge and one or more counterions.
5 more elements
Dependencies are inferred from the claim text.