Methods for controlling gram negative bacteria in mammals

A method for controlling gram negative bacteria in a mammal, comprising administering to a mammal a therapeutically effective amount of a compound having the formula:

• 19
• wherein,
• R1 is a hydrogen atom or a substituted or unsubstituted alkyl group;
• A is either a covalent bond connecting the cyclic ring to B or a substituted or unsubstituted alkylene diradical connecting the cyclic ring to B;
• B is a heterocyclic group;
• D is a substituted or unsubstituted alkyl group;
• the methylene carbon atoms of the cyclic rings are each independently substituted at one or more positions with one or two substitutents selected from hydrogen atoms, hydroxyl groups or substituted or unsubstituted alkyl groups;
• and
• the methine carbon atoms are each independently substituted with hydrogen atoms or substituted or unsubstituted alkyl groups, such that gram negative bacteria in the mammal is controlled.

A method for treating a state characterized by the presence of gram negative bacteria in a mammal, comprising administering to a mammal a therapeutically effective amount of compound having the formula:

• 21
• wherein,
• R1 is a hydrogen atom or a substituted or unsubstituted alkyl group;
• A is either a covalent bond connecting the cyclic ring to B or a substituted or unsubstituted alkylene diradical connecting the cyclic ring to B;
• B is a heterocyclic group;
• D is a substituted or unsubstituted alkyl group;
• the methylene carbon atoms of the cyclic rings are each independently substituted at one or more positions with one or two substitutents selected from hydrogen atoms, hydroxyl groups or substituted or unsubstituted alkyl groups;
• and
• the methine carbon atoms are each independently substituted with hydrogen atoms or substituted or unsubstituted alkyl groups, such that a state characterized by the presence of gram negative bacteria in a mammal is treated.

A method for controlling Helicobacter pylori in a mammal, comprising administering to a mammal a therapeutically effective amount of a compound having the formula:

• 23
• wherein,
• R1 is a hydrogen atom or a substituted or unsubstituted alkyl group;
• A is either a covalent bond connecting the cyclic ring to B or a substituted or unsubstituted alkylene diradical connecting the cyclic ring to B;
• B is a heterocyclic group;
• D is a substituted or unsubstituted alkyl group;
• the methylene carbon atoms of the cyclic rings are each independently substituted at one or more positions with one or two substitutents selected from hydrogen atoms, hydroxyl groups or substituted or unsubstituted alkyl groups;
• and
• the methine carbon atoms are each independently substituted with hydrogen atoms or substituted or unsubstituted alkyl groups, such that Helicobacter pylori in the mammal is controlled.

A method for treating a gastrointestinal disorder in a mammal characterized by having Helicobacter pylori as a causative agent, comprising administering to a mammal a therapeutically effective amount of a compound having the formula:

• 25
• wherein,
• R1 is a hydrogen atom or a substituted or unsubstituted alkyl group;
• A is either a covalent bond connecting the cyclic ring to B or a substituted or unsubstituted alkylene diradical connecting the cyclic ring to B;
• B is a heterocyclic group;
• D is a substituted or unsubstituted alkyl group;
• the methylene carbon atoms of the cyclic rings are each independently substituted at one or more positions with one or two substitutents selected from hydrogen atoms, hydroxyl groups or substituted or unsubstituted alkyl groups;
• and
• the methine carbon atoms are each independently substituted with hydrogen atoms or substituted or unsubstituted alkyl groups, such that a gastrointestinal disorder characterized by having Helicobacter pylori as a causative agent is treated.

A method for treating an ulcer associated with Helicobacter pylori in a mammal, comprising administering to a mammal a therapeutically effective amount of a compound having the formula:

• 28
• wherein,
• R1 is a hydrogen atom or a substituted or unsubstituted alkyl group;
• A is either a covalent bond connecting the cyclic ring to B or a substituted or unsubstituted alkylene diradical connecting the cyclic ring to B;
• B is a heterocyclic group;
• D is a substituted or unsubstituted alkyl group;
• the methylene carbon atoms of the cyclic rings are each independently substituted at one or more positions with one or two substitutents selected from hydrogen atoms, hydroxyl groups or substituted or unsubstituted alkyl groups;
• and
• the methine carbon atoms are each independently substituted with hydrogen atoms or substituted or unsubstituted alkyl groups, such that an ulcer associated with Helicobacter pylori in the mammal is treated.