Method of treatment for decreasing mortality resulting from congestive heat failure

A method of treatment for decreasing mortality resulting from congestive heart failure in mammals comprising internally administering to a mammal in need thereof an effective amount of a compound of Formula I:

• 4
• wherein:
• R1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl;
• R2 is hydrogen, lower alkyl of up to 6 carbon atoms or arylalkyl selected from benzyl, phenylethyl and phenylpropyl;
• R3 is hydrogen or lower alkyl of up to 6 carbon atoms;
• R4 is hydrogen or lower alkyl of up to 6 carbon atoms, or when X is oxygen, R4 together with R5 can represent —CH2—O—;
• X is a valency bond, —CH2, oxygen or sulfur;
• Ar is selected from phenyl, naphthyl, indanyl and tetrahydronaphthyl;
• R5 and R6 are individually selected from hydrogen, fluorine, chlorine, bromine, hydroxyl, lower alkyl of up to 6 carbon atoms, a —CONH2— group, lower alkoxy of up to 6 carbon atoms, benzyloxy, lower alkylthio of up to 6 carbon atoms, lower alkysulphinyl of up to 6 carbon atoms and lower alkylsulphonyl of up to 6 carbon atoms;
• or
• or a pharmaceutically acceptable salt thereof.

A method of treatment for decreasing mortality resulting from congestive heart failure in mammals comprising internally administering to a mammal in need thereof an effective amount of a therapeutic agent selected from the group consisting of an ACE inhibitor, a diuretic, and digoxin in conjunction with a compound of Formula I:

• 5
• wherein:
• R1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl;
• R2 is hydrogen, lower alkyl of up to 6 carbon atoms or arylalkyl selected from benzyl, phenylethyl and phenylpropyl;
• R3 is hydrogen or lower alkyl of up to 6 carbon atoms;
• R4 is hydrogen or lower alkyl of up to 6 carbon atoms, or when X is oxygen, R4 together with R5 can represent —CH2—O—;
• X is a valency bond, —CH2, oxygen or sulfur;
• Ar is selected from phenyl, naphthyl, indanyl and tetrahydronaphthyl;
• R5 and R6 are individually selected from hydrogen, fluorine, chlorine, bromine, hydroxyl, lower alkyl of up to 6 carbon atoms, a —CONH2— group, lower alkoxy of up to 6 carbon atoms, benzyloxy, lower alkylthio of up to 6 carbon atoms, lower alkysulphinyl of up to 6 carbon atoms and lower alkylsulphonyl of up to 6 carbon atoms;
• or
• or a pharmaceutically acceptable salt thereof.