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US 2001/0044433 A1Published application
Use of certain substituted caprolactams in treating tumors
AssigneeNovartis AG
InventorsFrederick Ray Kinder JR., Kenneth Walter Bair, Christopher Turchik Jagoe, Richard William Versace, Sompong Wattanasin
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Abstract
The present invention relates to certain substituted caprolactam compounds, pharmaceutical compositions containing said compounds, the use of said compounds in treating tumors and to a process for making said compounds.
Claims14
A compound of formula I:
- 14
- where
- R1 is (C1-6)alkyl or (C3-6)cycloalkyl;
- R2 is hydrogen or (C1-6)alkyl;
- X is (C1-12) alkylene;
- (C2-12) alkenylene;
- or (C2-12) alkynylene;
- m is 0 or 1;
- and
- R3 is (C3-8)cycloalkyl;
- or an aromatic ring system selected from II, III, IV and V:
- 15
- where
- R4 is hydrogen, chloro, or methoxy;
- R5 is hydrogen, chloro, (C1-18)alkyl or (C1-18)alkoxy;
- and Z is oxygen, sulfur, N—H, or N—CH3;
- or a pharmaceutically acceptable acid addition salt thereof, where possible.
14 more elements
Dependencies are inferred from the claim text.