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AssigneeEisai Co., Ltd.
InventorsMasako Tajima, Masakatsu Takanashi, Yukihasa Miyazawa, Toshio Takeshima, Kota Okinaga
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An EBV strain infecting epithelial cells and a stomach cancer cell line cancerated by EBV are established to clarify the mechanism of canceration of epithelial cells into stomach cancer by EBV and to develop a chemotherapeutic agent for stomach cancer cancerated by EBV. Further, a stomach cancer cell line stably producing EBV-related antigens is established to develop a diagnostic drug for stomach cancer cancerated by EBV. According to the present invention, GTC-4 cell line was established through culture of stomach cancer tissues. GTC-4 produced the EBV strain infecting epithelial cells and simultaneously produced EBV-related antigens stably in the supernatant.
A method of establishing an EBV-infected stomach cancer cell line, wherein stomach cancer tissues with a part of EBV genes observed in the cancer tissues are used.
EBV infecting cultured epithelial cells wherein a gene is not subjected to artificial recombination.
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