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US 2001/0044112 A1Published application
High throughput screening array containing porous material
OwnerMark B. Lylesinventor
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Abstract
Two dimensional arrays of molecules on a porous material are disclosed. Combinatorial arrays of molecules may include peptides, oligosaccharides, proteins, oligonucleotides, RNA, DNA, antibodies, and small organic molecules. The arrays can be used in high throughput screening methods to identify targets, receptors, hybridizing sequences, antibody epitopes, and other chemical and biological molecule-molecule interactions.
Claims36
A two dimensional array comprising molecules bound to a porous material surface;
- wherein:
- the array contains at least about 100 different molecules;
- and
- each of the different molecules is bound in a different predetermined region of the surface.
1 more element
A method for the detection of a target molecule in a sample, the method comprising:
- obtaining a two dimensional array comprising molecules bound to a porous material surface, wherein:
- the array contains at least about 100 different molecules;
- at least one of the different molecules is a partner molecule which binds to the target molecule;
- and
- each of the different molecules is bound in a different predetermined region of the surface;
- contacting the array and the sample to produce a partner molecule-target molecule complex;
- and
- detecting the partner molecule-target molecule complex.
5 more elements
Dependencies are inferred from the claim text.