Inhibition of mal1
AssigneePresident and Fellows of Harvard College
InventorGokhan S. Hotamisligil
Life of this patent
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Abstract
The invention provides compositions and methods of inhibiting Mal1 expression or function to treat lipid metabolisms disorders.
Claims20
A method of reducing the level of circulating free fatty acids in a mammal comprising, comprising administering to a compound that inhibits expression of mal1.
A method of inhibiting binding of a Mal1 in a cell, comprising contacting said cell with a compound that inhibits expression of Mal1.
A method of reducing the level of circulating free fatty acids in a mammal comprising, comprising administering to a mammal a compound that inhibits Mal1 activity.
A method of diagnosing insulin resistance or a predisposition thereto in a mammal, comprising determining the level of Mal1 transcripts or polypeptide in a tissue sample, wherein an increase in the level said transcripts or said polypeptide in said tissue compared to a normal control tissue indicates that said mammal is suffering from or predisposed to developing insulin resistance.
A method of diagnosing diabetes or a predisposition thereto in a mammal, comprising determining the level of Mal1 transcripts or polypeptide in a tissue sample, wherein an increase in the level of said transcripts or said polypeptide in said tissue compared to a normal control tissue indicates that said mammal is suffering from or predisposed to developing diabetes.
A method of diagnosing dyslipidemia or a predisposition thereto in a mammal, comprising determining the level of Mal1 transcripts or polypeptide in a tissue sample, wherein an increase in the level of said transcripts or said polypeptide in said tissue compared to a normal control tissue indicates that said mammal is suffering from or predisposed to developing dyslipidemia.
A method of diagnosing atherosclerosis or a predisposition thereto in a mammal, comprising determining the level of Mal1 transcripts or polypeptide in a tissue sample, wherein an increase in the level of said transcripts or said polypeptide in said tissue compared to a normal control tissue indicates that said mammal is suffering from or predisposed to developing atherosclerosis.
A method of diagnosing a predisposition to developing obesity, comprising determining the level of Mal1 transcripts or polypeptide in a tissue sample, wherein an increase in the level of said transcripts or said polypeptide in said tissue compared to a normal control tissue indicates that said mammal is predisposed to developing obesity.
Dependencies are inferred from the claim text.