Genes defferentially expressed in secretory versus proliferative endometrium
AssigneeAffymetrix, Inc.
InventorsJanet A. Warrington, Mamatha Mahadevappa
Life of this patent
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Abstract
The present invention compares expression profiles from matched samples to identify differential gene expression. Samples are matched according to physiological, pharmacological and/or disease state. Comparison of matched samples eliminates gene expression differences that are the result of changes in variables that are not of interest. The gene expression differences that remain can be attributed with a high degree of confidence to the unmatched variation. The gene expression differences thus identified can be used for example to diagnose disease, identify physiological state, design drugs, and monitor therapies.
Claims9
A method for diagnosing disease in an experimental sample comprising:
- measuring the physiological state of said experimental sample;
- selecting reference samples of known disease state that are similar to said experimental sample in physiological state;
- and
- comparing said experimental sample to said reference samples to identify the reference sample that matches said experimental sample;
- and
- diagnosing the experimental sample with the disease of the matching reference sample.
A method for diagnosing disease in an experimental sample comprising:
- measuring the physiological state of said experimental sample;
- selecting reference samples of known disease state that are similar to said experimental sample in physiological;
- and
- comparing the expression profile of said experimental sample to the expression profile of said reference samples to identify the reference sample that matches said experimental sample;
- and
- diagnosing the experimental sample with the disease of the matching reference sample.
A method for identifying markers to assay efficacy of drug therapies in women comprising:
- measuring the expression profile of a female sample before drug treatment and comparing it to the expression profile of a sample from the same subject after drug treatment.
A method to diagnose physiological disorders comprising:
- comparing a gene expression profile from an experimental sample to a gene expression profile that represents an average of a plurality of reference samples with matching indicators of physiological status.
A method to identify the physiological status of a sample of unknown origin comprising:
- generating an expression profile from the experimental sample, and
- comparing said expression profile to a plurality of expression profiles of known physiological state.
A method to identify markers of different physiological states in humans comprising:
- matching a sample from a first physiological state to a sample from a second physiological state;
- comparing the expression profiles from said first and second physiological states;
- and
- identifying genes that are differentially expressed in said first and second physiological states.
Dependencies are inferred from the claim text.