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US 2001/0043922 A1Published application
Complementary adenoviral vector systems and cell lines
OwnerImre Kovesdi, Douglas E. Brough +3inventors
InventorsImre Kovesdi, Douglas E. Brough, Duncan L. McVey, Joseph T. Bruder, Alena Lizonova
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Abstract
The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic method, particularly relating to gene therapy, vaccination, and the like, involving the use of such recombinants.
Claims35
An adenoviral vector that is deficient in two or more adenoviral gene functions.
A cell line selected from the group consisting of those cell lines designated as 293/E4, 293/ORF-6, and 293/E4/E2A.
Dependencies are inferred from the claim text.