Process for producing solid creatine dosage forms and dosage forms obtainable thereby
AssigneeBASF SE
InventorsKnut Kessel, Gunter Scherr, Thomas Bogenstatter, Gunther Berndl, Jorg Breitenbach
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Abstract
A process for producing solid creatine-containing dosage forms, wherein a) a mixture which comprises at least one thermoplastic, physiologically tolerated, water-soluble or water-swellable polymeric binder and creatine, and contains 1 to 20 mol of water per mol of creatine is prepared, b) the mixture is plasticated at or above the softening point of the polymeric binder, preferably with at least partial evaporation of the water, c) the plasticated mixture is shaped to dosage forms and cooled.
Claims9
A process for producing solid creatine-containing dosage forms, wherein
- a) a mixture which comprises at leat one thermoplastic, physiologically tolerated, water-soluble or water-swellable polymeric binder and creatine, and contains 1 to 20 mol of water per mol of creatine is prepared,
- b) the mixture is plasticated at or above the softening point of the polymeric binder,
- c) the plasticated mixture is shaped to dosage forms and cooled.
A creatine-containing solid dosage form comprising at least 3.3 mmol of creatine, based on the weight of the dosage form in g, in fine dispersion or molecular dispersion in a matrix composed of a thermoplastic, physiologically tolerated, water-soluble or water-swellable polymeric binder.
Dependencies are inferred from the claim text.