Device for delivery of multiple liquid sample streams to a mass spectrometer
AssigneesOle Hindsgaul, David C. Schriemer
InventorsOle Hindsgaul, David C. Schriemer
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Abstract
An electrospray apparatus employing multiple electrospray needles mounted on a rotatable plate sequentially delivers multiple sample streams to a mass spectrometer for analysis. The electrospray device includes an electrospray chamber, a rotatable needle supporting plate, a plurality of electrospray needles mounted on the plate, and a charger for applying a charge to droplets delivered to the electrospray chamber by the needles. The rotatable electrospray apparatus provides fast repetitive screening of simultaneously operating chromatography columns with a single mass spectrometer.
Claims14
An electrospray device for a mass spectrometer comprising:
- an electrospray chamber;
- a rotatable needle support;
- a plurality of electrospray needles mounted on the rotatable needle support, the electrospray needles connectable to a plurality of sample streams for delivery of droplets of one of the sample streams at a time to a mass spectrometer orifice of the electrospray chamber;
- and
- a charger for applying a charge to the droplets of the sample stream in the electrospray chamber and causing ions to be focused into a beam passing through the orifice into the mass spectrometer.
A method of delivering a plurality of sample streams to a mass spectrometer for sequential analysis, the method comprising:
- providing a plurality of sample streams to a plurality of electrospray needles mounted on a rotating plate;
- continuously spraying the sample streams with the electrospray needles;
- and
- sequentially positioning an outlet of each of the electrospray needles at delivery position for a predetermined dwell time by rotating and stopping the plate to deliver the sample streams to the mass spectrometer.
Dependencies are inferred from the claim text.