Implantable device for access to a treatment site

A drug delivery device comprising:

• a drug release device comprising a reservoir, and an orifice defined by a distal portion of the drug release device;
• a substantially hollow drug delivery catheter comprising a drug delivery catheter proximal end and a drug delivery catheter distal end, wherein the drug delivery catheter proximal end is coupled to the drug release device to provide a drug flow pathway from the reservoir, through the orifice, and through a lumen of the drug delivery catheter;
• and
• a stable positioning element for stably positioning at least a portion of the drug delivery device within a guide.

A drug delivery device comprising:

• a drug release device comprising a reservoir, and an orifice defined by a distal portion of the drug release device;
• a substantially hollow drug delivery catheter comprising a drug delivery catheter proximal end and a drug delivery catheter distal end, wherein the drug delivery catheter proximal end is coupled to the drug release device to provide a drug flow pathway from the reservoir, through the orifice, and through a lumen of the drug delivery catheter;
• and
• a sealing element for providing a liquid-resistant seal with a guide.

A system for delivery of drug to a treatment site comprising:

• an implantable guide comprising a proximal end, a distal end, and a guide body, wherein the guide body defines a lumen extending from the guide proximal end to the guide distal end;
• a drug delivery device, wherein at least a portion of the drug delivery device is removably and stably positioned within the guide lumen;
• and
• a stable positioning element that stably and removably associates the guide with the drug delivery device;
• wherein the drug delivery device is positioned for delivery of drug from a drug reservoir of the drug delivery device and through the distal end of the guide lumen to the treatment site.

A system for delivery of drug to a treatment site comprising:

• an implantable guide comprising a proximal end, a distal end, and a guide body, wherein the guide body defines a lumen extending from the guide proximal end to the guide distal end;
• a drug delivery device, wherein at least a portion of the drug delivery device is removably and stably positioned within the guide lumen;
• and
• a sealing element positioned between an inner wall of the guide lumen and an outer wall of the drug delivery device;
• wherein the drug delivery device is positioned for delivery of drug from a drug reservoir of the drug delivery device and through the distal end of the guide lumen.